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The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.
During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.
The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.
Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.
Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.
Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal sleep night | Sham Comparator | The first endurance test is the endurance motor control test after a normal sleep night. |
|
| Sleepless night | Experimental | The first endurance test is the endurance motor test after a sleepless night. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal sleep night | Behavioral | Usual hours of sleep |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Test duration | Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds. | 1 hour. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Xavier Drouot | Poitiers University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier de Poitiers | Poitiers | Vienne | 86021 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39593197 | Derived | Rault CCS, Heraud Q, Ansquer S, Ragot S, Kostencovska A, Thille AW, Stancu A, Saulnier PJ, Drouot X. Sleep Deprivation in Healthy Males Increases Muscle Afferents, Impairing Motor Preparation and Reducing Endurance. J Clin Neurophysiol. 2024 Nov 27;42(5):457-465. doi: 10.1097/WNP.0000000000001134. |
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To compare the motor endurance of healthy subjects after a normal sleep night and after a sleepless night.
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When analyzing the results (endurance, magnitude of the premotor potential), the outcomes assessor will not know if it is a normal night or a sleepless night
| Sleepless night |
| Behavioral |
Total sleep deprivation the first night |
|
| ID | Term |
|---|---|
| D012892 | Sleep Deprivation |
| ID | Term |
|---|---|
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |
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