Vitamin D Supplementation on in Major Orthopedic Surgery

Study of the Effect of Calcifediol Supplementation on Left Ventricular Function in Cardiopathic Patients Undergoing Major Orthopedic Surgery

Prospective, monocentric study in open, aimed at evaluating the effects of supplementation with calcifediol on left ventricular function parameters in cardiopathic subjects undergoing major orthopedic surgery.

Population of the study: 47 cardiopathic patients with hypovitaminosis D supplemented with calcifediol to reach vitamin D levels> 30 ng / ml within 6 months. The purpose of this study is to evaluate the improvement of the ejection fraction or GLS (global longitudinal strain) calculated by speckle tracking at 6 months in cardiopathic patients with vitamin D deficiency during functional recovery after major orthopedic surgery.

Inclusion Criteria:

• Age: > or equal to 55 years, < or equal to 85 years
• cardiopathic patients (including hypertension) who must undergo major orthopedic surgery at our site
• patients with diagnosis: hypovitaminosis d

Exclusion Criteria:

• presence of neoplasm
• endocrinological pathologies excluding diabetes mellitus
• advanced chronic renal failure (GFR < 35 ml/min)
• pregnant women
• impossibility to participate to the rehabilitation protocol or to perform the established controls