Right Ventricular Haemodynamic Evaluation and Response to Treatment

Right Ventricular Haemodynamic Evaluation and Response to Treatment

Mono-center Study to evaluate different multimodal functional parameter of the right ventricle in PAH-patients

Mono-center-study tu evaluate functional parameters in cardiac MRI, conductance catheter (pressure-volume-loops), echocardiography and right heart catheter in PAH patients and to compare different multimodal parameters

Inclusion Criteria:

• PH Nizza group 1 and patients without pulmonary hypertension after having the right heart catheter on clinical grounds

• ability to sign informed consent

• male and female between 18 to 85 years

• haemodynamic criteria:

  • Pulmonary vascular resistance (PVR) > 240 dyn x sec x cm-5
  • Mean Pulmonary artery pressure (mPAP) ≥ 25 mmHg for PAH patients

• normal haemodynamic in controls

• therapy-naive or at least since two months stabil therapy with approved drugs for PAH (Sildenafil, Tadalafil, Macitentan, Ambrisentan, Bosentan, Iloprost, Treprostinil, Riociguat).

Exclusion Criteria:

• therapy with positive inotropic drugs (dobutamin etc.)
• missing informed consent
• pregnancy or lactation