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| Name | Class |
|---|---|
| German Research Foundation | OTHER |
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Mono-center Study to evaluate different multimodal functional parameter of the right ventricle in PAH-patients
Mono-center-study tu evaluate functional parameters in cardiac MRI, conductance catheter (pressure-volume-loops), echocardiography and right heart catheter in PAH patients and to compare different multimodal parameters
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conductance catheter | Other | Contractility-measurement with conductance catheter (pressure-volume-catheter) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| conductance catheter | Diagnostic Test | pressure volume loops are assessed via a special catheter (Conductance catheter) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparibility of Ees (endsystolic elastance, which describes the right ventricular contractility) derived from conductance catheter, cMRI (cardiac magnetic resonance tomography) and 4D echocardiography | right ventricular contractility can be obtained via different methods, our aim is to compare the different methods. Ees is the endsystolic elastance which describes the contractility of the right ventricle | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| dp/dt max and min from Pressure-Wire vs. Conductance Katheter | delta pressure/delta time is an indirect parameter of right ventricular contractility, which is load dependent | 12 weeks |
| Comparibility of volumetry assessed via magnetic resonance tomography (MRI) and 4D echocardiography (ECHO) |
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Inclusion Criteria:
PH Nizza group 1 and patients without pulmonary hypertension after having the right heart catheter on clinical grounds
ability to sign informed consent
male and female between 18 to 85 years
haemodynamic criteria:
normal haemodynamic in controls
therapy-naive or at least since two months stabil therapy with approved drugs for PAH (Sildenafil, Tadalafil, Macitentan, Ambrisentan, Bosentan, Iloprost, Treprostinil, Riociguat).
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Khodr Tello, MD | Contact | 004964198556087 | khodr.tello@innere.med.uni-giessen.de | |
| Manuel Richter, MD | Contact | 004964198556022 | manuel.richter@innere.med.uni-giessen.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital Giessen | Recruiting | Giessen | 35392 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34972609 | Derived | Kremer N, Rako Z, Douschan P, Gall H, Ghofrani HA, Grimminger F, Guth S, Naeije R, Rieth A, Schulz R, Seeger W, Tedford RJ, Vadasz I, Vanderpool R, Wiedenroth CB, Richter MJ, Tello K. Unmasking right ventricular-arterial uncoupling during fluid challenge in pulmonary hypertension. J Heart Lung Transplant. 2022 Mar;41(3):345-355. doi: 10.1016/j.healun.2021.11.019. Epub 2021 Dec 5. | |
| 31500448 |
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| ID | Term |
|---|---|
| D018497 | Ventricular Dysfunction, Right |
| ID | Term |
|---|---|
| D018754 | Ventricular Dysfunction |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Volumes (end-diastolic and endystolic) are measured via MRI and ECHO and compared with each other |
| 12 weeks |
| Comparibility of pressures measured via pressure wire and conductance catheter | pressurewire measurements (high fidelity catheter) and conductance catheter (pressure volume catheter) are compared with each other | 12 weeks |
| Derived |
| Tello K, Wan J, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Mohajerani E, Seeger W, Herberg U, Sommer N, Gall H, Richter MJ. Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Sep;12(9):e009047. doi: 10.1161/CIRCIMAGING.119.009047. Epub 2019 Sep 10. |
| 30878422 | Derived | Tello K, Dalmer A, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Seeger W, Wilhelm J, Gall H, Richter MJ. Cardiac Magnetic Resonance Imaging-Based Right Ventricular Strain Analysis for Assessment of Coupling and Diastolic Function in Pulmonary Hypertension. JACC Cardiovasc Imaging. 2019 Nov;12(11 Pt 1):2155-2164. doi: 10.1016/j.jcmg.2018.12.032. Epub 2019 Mar 13. |
| 30616360 | Derived | Tello K, Dalmer A, Axmann J, Vanderpool R, Ghofrani HA, Naeije R, Roller F, Seeger W, Sommer N, Wilhelm J, Gall H, Richter MJ. Reserve of Right Ventricular-Arterial Coupling in the Setting of Chronic Overload. Circ Heart Fail. 2019 Jan;12(1):e005512. doi: 10.1161/CIRCHEARTFAILURE.118.005512. |