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For patients having a bone or joint infections, with or without device, optimal surgical therapy could be sometimes non-feasible, especially in the elderly population. Therefore, a medical therapy with oral prolonged suppressive antibiotic therapy (PSAT) seems to be an option to prevent recurrence and prosthesis loosening.
Subcutaneous (SC) administration of injectable intravenous antibiotics as prolonged suppressive antibiotic therapy could be a convenient way when oral treatment is not available to facilitate ambulatory care, this practice being considered as routine care.
The aim of this study is to evaluate tolerance and efficacy of subcutaneous administration of antibiotics for prolonged suppressive antibiotic therapy in patients having this treatment as part of their routine care.
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| Measure | Description | Time Frame |
|---|---|---|
| Description of sub-cutaneous administration of antibiotics for PSAT | In case of PSAT (prolonged suppressive antibiotic therapy), the duration could be several years. The data collected are: name of molecule, rough, posology, duration. | 60 months |
| Measure | Description | Time Frame |
|---|---|---|
| Tolerance of sub-cutaneous administration of antibiotics for PSAT | In case of PSAT (prolonged suppressive antibiotic therapy), the duration could be several years. This outcome will focus on severe adverse events induced by this sub-cutaneous and prolonged antibiotic therapy. Qualification of an adverse event is made using the CTCAE terminology: this terminology attributes a grade for every adverse event. There are 5 grades and a grade refers to the severity of the adverse event. A severe adverse event has a grade >=3. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients having bone or joint infection, with or without device
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Référence des Infections Ostéo-Articulaires complexes (CRIOAc Lyon) | Lyon | 69004 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31220276 | Derived | Pouderoux C, Becker A, Goutelle S, Lustig S, Triffault-Fillit C, Daoud F, Fessy MH, Cohen S, Laurent F, Chidiac C, Valour F, Ferry T; Lyon Bone and Joint Infection Study Group. Subcutaneous suppressive antibiotic therapy for bone and joint infections: safety and outcome in a cohort of 10 patients. J Antimicrob Chemother. 2019 Jul 1;74(7):2060-2064. doi: 10.1093/jac/dkz104. |
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| 60 months |
| Efficacy of sub-cutaneous administration of antibiotics for PSAT | A treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin. | 60 months |