Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy

A Virtual Clinical Trial to Assess the Impact of Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy

The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of dual energy computed tomography (DECT), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.

Eligibility Criteria:

Inclusion Criteria:

• Diagnosis of histologically proven primary or metastatic cancer requiring thoracic radiation therapy OR radiation therapy to the head and neck or brain
• At least 18 years of age.
• Planning to undergo proton or photon beam radiation therapy as part of the clinical management of the diagnosed cancer.
• Able to understand and willing to sign an IRB-approved written informed consent document.

Exclusion Criteria:

• Implanted metallic objects in the region to be scanned excepting dental prostheses
• IV or oral contrast medium within 24 hours prior to DECT image acqusition
• Pregnant.