Metabolomics of the Dietary Approaches to Stop Hypertension (DASH) Dietary Pattern

Metabolomics of the Dietary Approaches to Stop Hypertension (DASH) Dietary Pattern: A Secondary Data Analysis of the DASH Trial

The present record represents a secondary data analysis of the Dietary Approaches to Stop Hypertension (DASH) trial. Study data and specimens were accessed through the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen and Data Repository Coordinating Center (BioLINCC). A global, untargeted, metabolomic profile was used to investigate biomarkers of the DASH dietary pattern as well as blood pressure change.

The present study was conducted in order to: 1) quantify the metabolomic expression of the DASH dietary pattern; and 2) examine the relationship between metabolites that reflect the DASH dietary pattern and blood pressure change. This secondary data analysis leverages the completed DASH trial, a randomized feeding trial (N=459).

Inclusion Criteria:

• Men and women with systolic blood pressure <160 mmHg and diastolic blood pressure 80-95 mmHg

Exclusion Criteria:

• Taking anti-hypertensive medication
• Poorly controlled diabetes mellitus
• Hyperlipidemia
• Cardiovascular event within the past 6 months
• Chronic disease that may interfere with participation
• Pregnancy or lactation
• Body mass index > 35 kg/m2
• Unwilling to stop taking vitamin or mineral supplements or antacids
• Kidney disease
• Consumption of >14 alcoholic beverages per week
• Did not consent to the use of biological specimens
• Did not attend the 8 week follow-up visit
• No serum specimen or insufficient volume of serum specimens in repository