Patients will be imaged with MRE at the time of the RT planning MRI, prior to the induction of RT and immunotherapy. Research imaging will be in addition to standard imaging studies performed at time points consistent with the standard of care (at the time of the RT planning MRI and the first clinical follow-up). An additional MRE exam will be performed at the end of treatment outside the standard of care imaging.

Inclusion Criteria:

• Age ≥ 18 years
• Diagnosis of solid cancers with the presence of one or more liver metastases
• Minimum metastasis diameter ≥ 2 cm
• Planning to receive radiation therapy with immunotherapy
• Willingness to participate in mandatory imaging studies at Mayo Clinic Rochester

Exclusion Criteria:

• Contraindications for MRI including claustrophobia, pace maker, metal implants, aneurism clips
• Patients who are not able to consent

Radiation patients with liver metastases