Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults

Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Treatment of Acute Exacerbation of Chronic Bronchitis (AECB) and Community-acquired Pneumonia (CAP) in Adults

It is planned to compare the efficacy and safety of cefdinir and cefdinir/clavulanic acide treatments in acute exacerbation of chronic bronchitis (AECB) and community-acquired pneumoniae (CAP) patients.

Inclusion Criteria:

• The diagnosis of chronic bronchitis
• The diagnosis of community-acquired pneumoniae
• FEV1 value = 30-80%
• The diagnosis of mild-severe acute exacerbation of chronic bronchitis (AECB)
• Oxygen saturation < 90%

Exclusion Criteria:

• Pregnancy or breastfeeding
• Allergy against to penicillin or cephalosporins
• Renal impairment
• Active hepatic disease
• Antibiotic use except study drugs
• Immunosuppressive therapy before 6 months of study initiation
• Use of probenecid like drugs