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Participants (N=10/group) will consist of non-treatment seeking individuals with AUD.
Following informed consent and baseline screening, participants will partake in 3 stress induction sessions to assess their stress levels and cravings for alcohol. Participants will be randomized to receive either increasing doses of doxazosin XL (0, 4, and 8 mg) or placebo in a double-blind manner.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Doxazosin XL | Experimental | Participants will receive increasing doses of doxazosin XL (0, 4, and 8 mg). |
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| Placebo | Placebo Comparator | Participants will be randomized to receive a placebo for doxazosin XL. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Doxazosin XL | Drug | Participants will be randomized to receive increasing doses of doxazosin XL (0, 4, and 8 mg). |
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| Measure | Description | Time Frame |
|---|---|---|
| Feasibility as study attendance | Attending sessions | Two weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Stress as assessed by salivary cortisol levels | Cortisol levels will be measured using the Cortisol ELISA Kit (Enzo Life Sciences). | baseline |
| Stress as assessed by salivary cortisol levels | Cortisol levels will be measured using the Cortisol ELISA Kit (Enzo Life Sciences). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jin Ho Yoon, PhD | The University of Texas Health Science Center, Houston | Principal Investigator |
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| ID | Term |
|---|---|
| D000437 | Alcoholism |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D017292 | Doxazosin |
| ID | Term |
|---|---|
| D011224 | Prazosin |
| D011799 | Quinazolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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| Placebo | Drug | Participants will be randomized to receive a placebo for doxazosin XL. |
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| Friday of week 1 |
| Stress as assessed by salivary cortisol levels | Cortisol levels will be measured using the Cortisol ELISA Kit (Enzo Life Sciences). | Friday of week 2 |
| Stress as assessed by self-report | Self-reported stress on a questionnaire | baseline |
| Stress as assessed by self-report | Self-reported stress on a questionnaire | Friday of week 1 |
| Stress as assessed by self-report | Self-reported stress on a questionnaire | Friday of week 2 |
| Stress as assessed by heart rate | Self-reported stress on a questionnaire | baseline |
| Stress as assessed by heart rate | Self-reported stress on a questionnaire | Friday of week 1 |
| Stress as assessed by heart rate | Self-reported stress on a questionnaire | Friday of week 2 |
| stress reactivity as assessed by increased blood pressure | Blood pressure | baseline |
| stress reactivity as assessed by increased blood pressure | Blood pressure | Friday of week 1 |
| stress reactivity as assessed by increased blood pressure | Blood pressure | Friday of week 2 |
| Alcohol craving as assessed by the Penn Alcohol Craving Scale (PACS) | The Penn Alcohol Craving Scale (PACS) is a 5 question self-report measure that assesses alcohol craving in the past week. Each question ranges from 0 (no craving) to 6 (highest craving). The total score on the scale ranges from 0 to 30, and higher scores indicate greater alcohol craving. | baseline |
| Alcohol craving as assessed by the Penn Alcohol Craving Scale (PACS) | The Penn Alcohol Craving Scale (PACS) is a 5 question self-report measure that assesses alcohol craving in the past week. Each question ranges from 0 (no craving) to 6 (highest craving). The total score on the scale ranges from 0 to 30, and higher scores indicate greater alcohol craving. | Friday of week 1 |
| Alcohol craving as assessed by the Penn Alcohol Craving Scale (PACS) | The Penn Alcohol Craving Scale (PACS) is a 5 question self-report measure that assesses alcohol craving in the past week. Each question ranges from 0 (no craving) to 6 (highest craving). The total score on the scale ranges from 0 to 30, and higher scores indicate greater alcohol craving. | Friday of week 2 |
| Alcohol Demand as assessed by the Brief Assessment of Alcohol Demand (BAAD) questionnaire | Alcohol demand will be assessed via the Brief Assessment of Alcohol Demand (BAAD), a 3-item questionnaire ("If drinks were free, how many would have?", "What is the maximum total amount you would spend on drinking?"; and "What is the maximum you would pay for a single drink?"). | baseline |
| Alcohol Demand as assessed by the Brief Assessment of Alcohol Demand (BAAD) questionnaire | Alcohol demand will be assessed via the Brief Assessment of Alcohol Demand (BAAD), a 3-item questionnaire ("If drinks were free, how many would have?", "What is the maximum total amount you would spend on drinking?"; and "What is the maximum you would pay for a single drink?"). | Friday of week 1 |
| Alcohol Demand as assessed by the Brief Assessment of Alcohol Demand (BAAD) questionnaire | Alcohol demand will be assessed via the Brief Assessment of Alcohol Demand (BAAD), a 3-item questionnaire ("If drinks were free, how many would have?", "What is the maximum total amount you would spend on drinking?"; and "What is the maximum you would pay for a single drink?"). | Friday of week 2 |
| Delay discounting for alcohol as assessed by a computerized task | Delay discounting will be assessed for both money and alcohol using a computerized task at weekly clinic visits. Delays will range from 1 day to 25 years, and monetary values will range from $0 to $1,000. In the case of alcohol discounting, the unit of alcohol (e.g., bottle, shot, glass, etc.) and cost of alcohol will be individually assessed in order to present choices that are monetarily equivalent to the money discounting task. | baseline |
| Delay discounting for alcohol as assessed by a computerized task | Delay discounting will be assessed for both money and alcohol using a computerized task at weekly clinic visits. Delays will range from 1 day to 25 years, and monetary values will range from $0 to $1,000. In the case of alcohol discounting, the unit of alcohol (e.g., bottle, shot, glass, etc.) and cost of alcohol will be individually assessed in order to present choices that are monetarily equivalent to the money discounting task. | Friday of week 1 |
| Delay discounting for alcohol as assessed by a computerized task | Delay discounting will be assessed for both money and alcohol using a computerized task at weekly clinic visits. Delays will range from 1 day to 25 years, and monetary values will range from $0 to $1,000. In the case of alcohol delay discounting, the unit of alcohol (e.g., bottle, shot, glass, etc.) and cost of alcohol will be individually assessed in order to present choices that are monetarily equivalent to the money discounting task. | Friday of week 2 |
| Delay Discounting for money as assessed by a computerized task | Delay discounting will be assessed for both money and alcohol using a computerized task at weekly clinic visits. Delays will range from 1 day to 25 years, and monetary values will range from $0 to $1,000. | baseline |
| Delay Discounting for money as assessed by a computerized task | Delay discounting will be assessed for both money and alcohol using a computerized task at weekly clinic visits. Delays will range from 1 day to 25 years, and monetary values will range from $0 to $1,000. | Friday of week 1 |
| Delay Discounting for money as assessed by a computerized task | Delay discounting will be assessed for both money and alcohol using a computerized task at weekly clinic visits. Delays will range from 1 day to 25 years, and monetary values will range from $0 to $1,000. | Friday of week 2 |
| Alcohol use as assessed by self-report | Self-reported drinks per day for the past week | baseline |
| Alcohol use as assessed by self-report | Self-reported drinks per day for the past week | Friday of week 1 |
| Alcohol use as assessed by self-report | Self-reported drinks per day for the past week | Friday of week 2 |
| D006571 | Heterocyclic Compounds |