Quantification of Nerve Stiffness in Neuropathies

Quantification of Nerve Stiffness in Patients with Peripheral Neuropathies

This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial.

Participants will be asked to remain relaxed during elastography measurements.

Inclusion Criteria:

• Male or female aged 18 to 65
• Having social insurance status
• Having given informed consent
• Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)>15,000 BTU)

Exclusion Criteria:

For controls:

• Person staying in a health or social facility
• Person unable to understand the protocol and to respect the modalities
• Person deprived of liberty
• Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
• Participation in another biomedical research in progress
• Diabetes, history of neuromuscular disease

For CIDP:

• Person staying in a health or social facility
• Person unable to understand the protocol and to respect the modalities
• Person deprived of liberty
• Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
• Participation in another biomedical research in progress
• MRC score < 3

For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG:

• Person staying in a health or social facility
• Person unable to understand the protocol and to respect the modalities
• Person deprived of liberty
• Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
• Participation in another biomedical research in progress