Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome

Effect of Adding Vitamin D Supplement to Clomiphene Citrate for Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome

The aim of this work is to evaluate the effect of vitamin D supplementation in overweight infertile women with PCOs undergoing induction of ovulation.

The study will include overweight infertile women with PCOS seeking fertility who will receive induction of ovulation by clomiphene citrate will be recruited and randomized into two groups:

Group A (study group): 93 women who will receive clomiphene citrate for induction of ovulation with vitamin D and calcium supplement

Group B (control group): 93 women who will receive clomiphene citrate for induction of ovulation with placebo and calcium supplement

Inclusion Criteria:

• polycystic ovarian syndrome diagnosis made according to ESHRE/ASRM criteria.
• infertility is the cause for seeking treatment.
• overweight females with BMI more than 25 but less than 30.

Exclusion Criteria:

• causes of infertility other than PCOS.
• causes of anovulation other than PCOS.
• current or in last six months use of hormonal treatment.
• contraindication to any drug used in the study.