To study the effects of green coffee supplement on adropin, irisin, vaspine, systemic inflammation and oxidative stress in breast cancer survivors.50 breast cancer survivors who their treatment is over and referred to follow breast cancer clinic with will be randomly allocated to receive placebos or 2 capsules green coffe for 12 weeks; both groups will be advised to adherence the investigators' diet and exercise program too. At the first and the end of the intervention, adropin, irisin, vaspine, systemic inflammation and oxidative stress will be assessed and compared between groups.

Inclusion Criteria:

• Age of 18 to 70 years
• Body Mass Index (BMI) between 25-40 treatment is over

Exclusion Criteria:

• Taking any kind of supplement for weight reduction
• pregnancy or lactation
• Professional athletes