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| Name | Class |
|---|---|
| Odense University Hospital | OTHER |
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This is an intersectional and interdisciplinary screening program in Viborg Municipality, including 67 years old citizens. This observational study will estimate the cost-effectiveness of a combined screening program for the following conditions: Abdominal aortic aneurysm, peripheral arterial disease, carotid plaque, hypertension, arrhythmia, and type-2-diabetes. Furthermore, the incidence of the outlined conditions will be described and so will the result of the intervention initiated (secondary medical prophylaxis, smoking cessation, introduction to nutritionally deficient diet etc.)
Description of the cohort: All Viborg municipality citizen are invited to the combined screening program around there 67th birthday. Participants with positive screening results are offered following up consultations and prophylactic interventions are initiated (secondary medical prophylaxis, smoking cessation, introduction to nutritionally deficient diet etc.)
67 years-old citizens from the surrounding municipalities without the offer of the combined screening are used as a control group (1 case: 5 controls).
There are no exclusion criteria.
The screening examination includes: Blood pressure in both arms, ankle brachial blood pressure index (ABI), ultrasound for carotid plaque and abdominal aortic aneurysm, HbA1c and pulmonary function test. Furthermore, a questionnaire on lifestyle parameters, BMI, medical history, walking-related pain and self-rated quality of life (EQ-5D).
One year after the screening examination, the participants will receive a questionnaire in order to evaluate the effect from a participant perspective. The cost(-effectiveness) of the screening program will be estimated after 5 years based on prevalence of diseases, response rate, data extraction from nationwide registries and existing evidence of disease prevention.
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| Measure | Description | Time Frame |
|---|---|---|
| Baseline prevalence of peripheral arterial disease (PAD) in men and women aged 67 years from a population screening study on the Municipal of Viborg. | Ankel Brachial Index | Inclusion will take place from sep. 2014 to sep. 2020 |
| Baseline prevalence of abdominal aortic aneurysm (AAA) | Ultra sound examination (AP diameter (mm)) | Inclusion will take place from sep. 2014 to sep. 2020 |
| Baseline prevalence of diabetes | Bedside HbA1c | Inclusion will take place from sep. 2014 to sep. 2020 |
| Baseline prevalence of hypertension | BP(mmhg) | Inclusion will take place from sep. 2014 to sep. 2020 |
| Baseline prevalence of cardiac arrythmia | ECG | Inclusion will take place from sep. 2014 to sep. 2020 |
| Baseline prevalence of carotic plaques | Ultra sound examination of A. carotis (IMT in mm) | Inclusion will take place from sep. 2014 to sep. 2020 |
| Measure | Description | Time Frame |
|---|---|---|
| The cost(-effectiveness) of the screening program | Socio-economic evaluation (national register data), QALY | 5 years after ending inclusion |
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Inclusion Criteria:
All Viborg municipality citizen are invited to the combined screening program around there 67th birthday.
Exclusion Criteria:
There are no exclusion criteria.
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All Viborg municipality citizen are invited to the combined screening program around there 67th birthday. Participants with positive screening results are offered following up consultations and prophylactic interventions are initiated (secondary medical prophylaxis, smoking cessation, introduction to nutritionally deficient diet etc.)
67 years-old citizens from the surrounding municipalities without the offer of the combined screening are used as a control group (1 case: 5 controls).
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| Name | Affiliation | Role |
|---|---|---|
| Annette Høgh, MD, PhD | Steering Committee | Study Chair |
| Marie Dahl, MSc(nurse) | Steering Committee | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular research Center (KVC), Viborg Hospital | Viborg | 8800 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41436274 | Derived | Van Der Giessen D, Hogh A, Svenstrup D, Lindholt JS, Dahl M. Clinical relevance of screening for ECG abnormalities in 67-year-old Danes: a population-based cohort study from the Viborg Screening Programme (VISP). BMJ Open. 2025 Dec 23;15(12):e104169. doi: 10.1136/bmjopen-2025-104169. | |
| 40130283 | Derived | Gras Hojgaard H, Hogh AL, Lindholt JS, Frederiksen K, Dahl M. Effect of nurse-led telephone follow-up to optimize adherence to preventive medication after screen-detected cardiovascular disease: a randomized controlled trial. Eur J Cardiovasc Nurs. 2025 Jul 21;24(5):748-759. doi: 10.1093/eurjcn/zvaf047. |
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| 39926308 | Derived | Andersen JW, Hogh A, Lindholt JS, Sogaard R, Stovring H, Yderstraede KB, Sandbaek A, Dahl M. Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort. Clin Epidemiol. 2025 Feb 5;17:75-85. doi: 10.2147/CLEP.S487825. eCollection 2025. |
| 38997668 | Derived | Dahl M, Andersen JW, Lindholt J, Krarup NT, Borregaard B, Uberg N, Hogh A. Prevalence of interarm blood pressure difference is notably higher in women; the Viborg population-based screening program (VISP). BMC Public Health. 2024 Jul 12;24(1):1868. doi: 10.1186/s12889-024-19388-8. |
| 36854592 | Derived | Hogh A, Lindholt JS, Sogaard R, Refsgaard J, Svenstrup D, Moeslund NJ, Bredsgaard M, Dahl M. Protocol for a cohort study to evaluate the effectiveness and cost-effectiveness of general population screening for cardiovascular disease: the Viborg Screening Programme (VISP). BMJ Open. 2023 Feb 28;13(2):e063335. doi: 10.1136/bmjopen-2022-063335. |
| ID | Term |
|---|---|
| D017544 | Aortic Aneurysm, Abdominal |
| D006973 | Hypertension |
| D058729 | Peripheral Arterial Disease |
| D001145 | Arrhythmias, Cardiac |
| D003920 | Diabetes Mellitus |
| D002340 | Carotid Artery Diseases |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D001014 | Aortic Aneurysm |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D001018 | Aortic Diseases |
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D016491 | Peripheral Vascular Diseases |
| D006331 | Heart Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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