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Fentanyl is analgesia medication. There has not pain nerve in the lung. Flexible bronchoscopy(FB) is used in the respiratory medicine. So people will not feel pain in the process of FB. The purpose of the study is to know if Fentanyl is useful in the conscious sedation of FB.
Fentanyl is opioid receptor agonists. It is a fast-acting, short duration and potent analgesics.
Flexible bronchoscopy (FB) is mostly used in the diagnosis and therapy in the respiratory disease. As we know, there has not pain nerve in the lung. People will not feel pain when they are in FB.
If fentanyl will be effective in FB? Our study will observe the effect of conscious sedation in FB with fentanyl or without fentanyl.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FB with fentanyl | Experimental | In the Bispectral Index monitoring,our study will use midazolam, propofol and fentanyl in the conscious sedation of FB |
|
| FB without fentanyl | Active Comparator | In the Bispectral Index monitoring, our study will use midazolam, propofol in the conscious sedation of FB |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fentanyl | Drug | Five minutes before the patients is done the flexible bronchoscopy, fentanyl will be intravenous injected. |
|
| Measure | Description | Time Frame |
|---|---|---|
| perioperative changes of blood pressure | For each patient,bispectral index monitoring after anesthesia. Bp will be measured. | every 5 minutes from the operation beginning to end |
| Measure | Description | Time Frame |
|---|---|---|
| perioperative time | For each patient, record the time bronchoscopy in and out | from the operation beginning to end |
| Adverse events | For each patient, Adverse events (overall intraoperative cough,bleeding,low oxygen solution) will be record in the operation |
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Inclusion Criteria:
Cough reflex is good agree to do bronchoscopy agree to take part in the study no the contraindication of bronchoscopy
Exclusion Criteria:
Forced expiratory volume in one second<1 L severe hemoptysis severe heart, liver,kidney failure psychiatric and nervous disorders allergic to the anesthetic ( fentanyl, midazolam, or propofol)
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| Name | Affiliation | Role |
|---|---|---|
| wei gu, master | The First Affiliated Hospital with Nanjing Medical University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19443532 | Result | Clark G, Licker M, Younossian AB, Soccal PM, Frey JG, Rochat T, Diaper J, Bridevaux PO, Tschopp JM. Titrated sedation with propofol or midazolam for flexible bronchoscopy: a randomised trial. Eur Respir J. 2009 Dec;34(6):1277-83. doi: 10.1183/09031936.00142108. Epub 2009 May 14. | |
| 22045879 | Result | Wahidi MM, Jain P, Jantz M, Lee P, Mackensen GB, Barbour SY, Lamb C, Silvestri GA. American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients. Chest. 2011 Nov;140(5):1342-1350. doi: 10.1378/chest.10-3361. |
| Label | URL |
|---|---|
| Titrated sedation with propofol or midazolam for flexible bronchoscopy: a randomised trial. | View source |
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| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D008874 | Midazolam |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001569 | Benzodiazepines |
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| Midazolam | Drug | Five minutes before the patients is done the flexible bronchoscopy, midazolam will be intravenous injected. |
|
|
| Propofol | Drug | Propofol will be intravenous injected as soon as the flexible bronchoscopy begins. |
|
|
| Bispectral Index monitoring | Device | Bispectral Index monitoring will be used in the process of the flexible bronchoscopy. |
|
| in the process of the operation |
| Patient satisfaction rate | One day after the patient do the bronchoscopy, ask him/her about the satisfaction to the operation | One day after the operation |
| American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients. | View source |
| D001552 |
| Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |