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The main goal of this study is to compare wound infiltration with ketorolac versus lidocaine for postoperative analgesia in total abdominal hystrectomy (TAH) operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine Hydrochloride | Active Comparator | Wound infiltration with Lidocaine |
|
| Ketorolac tromethamine | Active Comparator | Wound infiltration with Ketorolac |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wound infiltration | Procedure | Before skin closure,the subcutaneous tissue and skin all around the wound will be infiltrated by 20 mL of the drug then closure of the skin will be done. |
| Measure | Description | Time Frame |
|---|---|---|
| Rescue analgesia time | Time for first analgesia requirement | First 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Patient's pain score | Pain score will be done by visual analog scale (VAS) (minimum 0 = no pain, while maximum 10 cm = worst possible pain). Pain score will be recorded just after extubation (taken as 0 h) and after 1, 2, 4, 6, 12, 18 and 24 h later. Patients will be instructed about the usage of VAS scalebefore the operation. | First 24 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
Patients with the following criteria will be excluded from the study;
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University hospitals | Cairo | 11591 | Egypt |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D020911 | Ketorolac Tromethamine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| Lidocaine Hydrochloride | Drug | 20 ml of 1% Lidocaine solution |
|
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| Ketorolac tromethamine | Drug | 20 mL of saline with 30 mg ketorolac |
|
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| The total analgesic consumption | Postoperative analgesia will be provided with intramuscular (IM) meperidine 50 mg to both groups when the VAS score is ≥4. The total meperidine consumption will be recorded. | First 24 hours postoperatively |
| Aniline Compounds |
| D000588 | Amines |
| D007213 | Indomethacin |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |