The purpose of this study is to compare postoperative pain following COX-2 and prostanoids expression in women who underwent laparoscopic surgery for female genital disease in order to evaluate the effect of COX-2 on local inflammation, COX-2 and prostanoids expression followed by exposure time to carbon dioxide(CO2) gas, and degree of postoperative pain.

In women who underwent laparoscopic surgery for female genital disease, the effect of COX-2 on local inflammation was assessed by randomization, using the COX-2 inhibitor celecoxib and placebo, comparative evaluation of expression of COX-2 and prostanoids by pre/postoperative peritoneal biopsy and postoperative pain depending on gas exposure time

Inclusion Criteria:

• Female, Age ≥ 20 years
• Patients with benign female genital disease who need laparoscopic surgery
• Patients with benign disease who can be treated by single port laparoscopy
• Patients who signed an approved informed consent

Exclusion Criteria:

• Female, Age < 20 years
• Pregnancy
• Previous cancer history
• Patients who refuse to sign an informed consent
• Patients with benign female genital disease combined clinical peritonitis (ex. tubo-ovarian abscess, tubo-ovaritis, ruptured endometriosis)
• Patients with malignant female genital disease
• Patients who got surgery with multi-port laparoscopy
• Patients who are contraindicated with COX-2 inhibitors (liver disease, renal disease, active peptic ulcer, active gastrointestinal tract bleeding, ischemic heart disease, hyperkalemia)