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the effect using low dose levo thyroxine in pregnant females with TSH level more than 2.5 mU/L in the first trimester on pregnancy outcome
the study aim to detect the effect of low dose levothyroxine 50 ug on pregnant females and compare it with others receiving placebo
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| levothyroxine | Active Comparator | 100 pregnant female with TSH of> 2.5 mU/L but less than 4 mU/L after biochemical diagnosis of pregnancy will receive 50 ug of levothyroxine (eltroxin 50) aspen,Egypt throughout the pregnancy |
|
| control | No Intervention | 100 pregnant female with TSH of> 2.5 mU/L but less than 4 mU/L after biochemical diagnosis of pregnancy will not receive any drug throughout the pregnancy |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| levothyroxin | Drug | 90 female received levothroxine |
|
| Measure | Description | Time Frame |
|---|---|---|
| 1st trimester miscarriage | 1st trimester spontaneous or missed abortion | during 1st 13 weeks of pregnancy |
| Measure | Description | Time Frame |
|---|---|---|
| adverse pregnancy outcome | 2nd trimesteric missed or spontaneous abortion ,gestational hypertension,preeclampsia, anemia, abruptio placenta premature delivery , fetal growth restriction, low birth weight | last 26 week of gestation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AinShams university maternity hospital | Cairo | Abbassya | Egypt |
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| ID | Term |
|---|---|
| D013974 | Thyroxine |
| ID | Term |
|---|---|
| D013963 | Thyroid Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D024322 | Amino Acids, Aromatic |
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| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |