Circulating P3NP and Cardiovascular Events in Hemodialysis Patients

Involvement of Circulating Aminoterminal Propeptide of Type 3 Procollagen in Cardiovascular Events in Patients on Hemodialysis

This study evaluates whether circulating levels of aminoterminal propeptide of type III procollagen (PIIINP) can predict the cardiovascular events in hemodialysis patients.

Type III collagen abundantly exists in the cardiovascular system including the aorta and heart. The aminoterminal propeptide of type III procollagen (PIIINP) is an extension peptide of type III procollagen, which is cleaved off stoichiometrically during conversion from type III procollagen to type III collagen and liberated to serum. Elevated serum concentrations of PIIINP are considered a marker of higher collagen turnover and tissue fibrosis including the heart and vascular system. In this study, the investigators prospectively examined whether serum levels of PIIINP could be a biomarker for predicting cardiovascular events in hemodialysis patients.

Inclusion Criteria:

• End-stage kidney disease patients who had been undergoing maintenance hemodialysis over one year in Toujinkai Hospital at the point of January 1, 2005

Exclusion Criteria:

• Histories of coronary events and/or interventions
• Congestive heart failure of New York Heart Association grades III to IV
• Moderate or worse valvular heart disease
• Permanent pacemaker implantation
• Idiopathic cardiomyopathy
• Chronic obstructive pulmonary disease
• Malignancy
• Acute hepatitis, chronic hepatitis, or liver cirrhosis including carrier of hepatitis virus