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| Name | Class |
|---|---|
| BioMérieux | INDUSTRY |
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LRTI (Lower respiratory tract infection) is a severe disease in China. The fast and accurate diagnosis of pathogens, bacteria or viruses that cause the infection is critical for the therapy. In this study, investigators assume that the use of FilmArray Respiratory Panel will provide more rapid and comprehensive evidences to physicians to diagnose LRTI which is caused by viruses or atypical pathogens and then reduce the length of antibiotics use by 0.5-1.0 days as well as other hospital resources (length of hospital/ICU stay, take-away oral antibiotics, etc.). Secondly, investigators assume that in LRTI patients with viral infection and a low serum PCT level, fewer length of antibiotics use can be expected. Thirdly, the use of FilmArray Respiratory Panel will provide clearer epidemiology data of virus and atypical pathogens in hospitalized LRTI patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FilmArray group | Experimental | Patients in this group will use FilmArray Respiratory Panel to test potential viral pathogens. |
|
| Routine test group | No Intervention | Patients in this group will use clinical routine methods to test potential viral pathogens. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FilmArray Respiratory Panel | Diagnostic Test | An Multi-PCR method which can detect 20 pathogens in 45 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The length (days) of antibiotics therapy in hospital between two groups. | The duration of antibiotics used is defined as days of intravenous antibiotic therapy in which any doses of antibiotics are administered. | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Antibiotics therapy cost | From in-hospital to discharge or death, whichever came first, assessed up to 12 months | |
| Length of hospital stay (LOS) and/or ICU stay | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shengchen DUAN, doctor | Contact | 13488779977 | doctordsc@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chian Japan Friendship Hospital | Recruiting | Beijing | Beijing Municipality | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31229593 | Derived | Shengchen D, Gu X, Fan G, Sun R, Wang Y, Yu D, Li H, Zhou F, Xiong Z, Lu B, Zhu G, Cao B. Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial. Clin Microbiol Infect. 2019 Nov;25(11):1415-1421. doi: 10.1016/j.cmi.2019.06.012. Epub 2019 Jun 20. |
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| The correlation between the initial serum PCT level and clinical outcomes/mortality | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |
| The detection rate of viruses and atypical pathogens by FilmArray in LRTI patients | From in-hospital to discharge or death, whichever came first, assessed up to 12 months |