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| ID | Type | Description | Link |
|---|---|---|---|
| DRKS00013589 | Registry Identifier | DRKS | |
| AZ 156/17 | Other Identifier | Ethik-Kommission Giessen |
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Measurement of the endtidal carbon dioxide by capnography to exclude or to ensure the diagnosis pulmonary hypertension. The aim of the study is to obtain an endtidal carbon dioxide cut-off value for the diagnostic algorithm for pulmonary hypertension as an easily measurable and cheap diagnostic tool in patients with suspicion of pulmonary hypertension.
The disease pulmonary hypertension is due to a remodeling of the lung vessels which results in a change of the exhaled air. This change is measurable with a so called capnograph. The investigators want to measure the breath from patients with and without pulmonary hypertension to detect a cut-off value for the diagnosis pulmonary hypertension.
Patients which have the probably diagnosis pulmonary hypertension and are older than 18 years are investigated. This patients will get an right heart catheterization and a measurement from their exhaled air.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Suspicion of pulmonary hypertension | At Patients with suspicion of pulmonary hypertension, which get a right heart catheterization, in the context of the study the exhaled air, precious the endtidal carbon dioxide (CO2), before or after the right heart catheterization will be measured through capnography. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Capnography | Diagnostic Test | Measuring of the exhaled air, especially endtidal co2, through capnography. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measurement PetCO2 | Measurement PetCO2 by capnography at rest after or before a right heart catheterization, comparison of the parameter between patients with and without | At baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Establishing a cut-off | Establishing a cut-off for the non-invasive diagnosing of pulmonary hypertension, which differs between patients with and without pulmonary hypertension and save patients without the disease before a dispensable invasive right heart catheterization | At baseline |
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Inclusion Criteria:
Age > 18 years, suspicion of pulmonary hypertension, planned or accomplished right heart catheterization
Exclusion Criteria:
none
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Patients of a tertiary referral center retro- and prospective part of the study.
Afterwards in a next prospective study part patients in ambulant setting.
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| Name | Affiliation | Role |
|---|---|---|
| Henning Gall, MD, PhD | University Clinic Giessen and Marburg - Campus Giessen | Principal Investigator |
| Werner Seeger, Prof. | University Clinic Giessen and Marburg | Study Director |
| Ardeschir Ghofrani, Prof. | University Clinic Giessen and Marburg | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Clinic Giessen and Marburg | Giessen | Hesse | 35392 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21622547 | Background | Hemnes AR, Pugh ME, Newman AL, Robbins IM, Tolle J, Austin ED, Newman JH. End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment. Chest. 2011 Nov;140(5):1267-1273. doi: 10.1378/chest.11-0155. Epub 2011 May 26. |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D065627 | Familial Primary Pulmonary Hypertension |
| D014652 | Vascular Diseases |
| D008171 | Lung Diseases |
| D000081029 | Pulmonary Arterial Hypertension |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D019296 | Capnography |
| ID | Term |
|---|---|
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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