Efficacy of Two Onabotulinum Toxin Doses

Comparing the Efficacy of Two Doses of Onabotulinum Toxin for the Treatment of Neurogenic Detrusor Overactivity - a Retrospective Cohort Study

The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively. The records of all patients treated with Onabotulinum toxin injections into the detrusor since 2000 will be evaluated. The changes in the urodynamic values after the injection of 300 units of Onabotulinum toxin will be compared with the changes after the injection of 200 units. Furthermore, the differences in urinary continence, duration between injections, side effects and complications between the two groups will be investigated.

Inclusion Criteria:

• neurogenic detrusor overactivity
• spinal cord injury
• Onabotulinum toxin injections into the detrusor from 2000-2017

Exclusion Criteria:

• missing urodynamic values before or after Onabotulinum toxin injections