Efficacy of Resveratrol in Depression

Efficacy and Safety of Resveratrol in the Treatment of Depression: Double-blind Randomized Placebo-controlled Parallel-group Study.

Patients with depression (target number - 60) receive resveratrol 500 mg or placebo (1:1) each morning daily for 1 month with primary outcome measures of the score change on depression rating scale HDRS-17 and change in SIRT1 activity in the blood measured 4 times over the study period (before, in the middle, after the intervention, and in 2 week follow up).

Inclusion Criteria (selectively):

• MDD recurrent or with single episode with melancholic features or dysthymia (DSM-5);
• current depression.

Exclusion Criteria (selectively):

• serious or unstable disease;
• antidepressants intake.