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Evaluation of metabolic profile of users of hormonal and non-hormonal contraceptives during five years follow-up
Were eligible for the study 489 Women, followed in Federal University of São Paulo Family Planning Service, who used the same contraceptive method during five year of follow-up, According to the service protocol, the patients, after had participated of a orientation group about contraceptives methods, elected one of them. After that, if the choice had been according to the eligibility criteria of World Health Organization, it was approved by a gynecologist.
The contraceptive methods available were the intrauterine device (IUD) oral contraceptives, including combined pills and progestin-only formulations, and depot medroxyprogestereone acetate.
The study consisted in the evaluation of their medical records of weight, BMI, Blood pressure, glycemia, seric levels of cholesterol and triglycerides, during the five years, and in the comparison of the differences of these data between the contraceptive methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-hormonal contraceptive | Users of non- hormonal intrauterine device during the 5 years follow-up |
| |
| Hormonal contraceptives | Users of combined oral contraceptive, progestin-only pills, depot-medroxyprogestereone acetate during 5 years follow-up |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intrauterine device | Device | Use of Intrauterine device during the follow-up period |
|
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index | evaluation of variation of body mass index during the usage of hormonal and non-hormonal contraceptives | five years follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| glycemia | evaluation of variation of glycemia during the usage of hormonal and non-hormonal contraceptives | five years follow-up |
| cholesterol level | evaluation of variation of cholesterol serum levels during the usage of hormonal and non-hormonal contraceptives |
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Inclusion Criteria:
Exclusion Criteria:
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women in menacme, users of the same contraceptive hormonal (combined oral contraceptives, progestin-only pills and depot-medroxyprodestereone acetate) and non-hormonal contraceptive methods (IUD) during five years
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Federal University of Sao Paulo - Unifesp | São Paulo | São Paulo | 0-4023- 062 | Brazil |
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| ID | Term |
|---|---|
| D003268 | Contraception Behavior |
| D024821 | Metabolic Syndrome |
| D001836 | Body Weight Changes |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D043762 | Reproductive Behavior |
| D001519 | Behavior |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
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| ID | Term |
|---|---|
| D007434 | Intrauterine Devices |
| D003277 | Contraceptives, Oral, Combined |
| D017258 | Medroxyprogesterone Acetate |
| ID | Term |
|---|---|
| D003274 | Contraceptive Devices, Female |
| D003273 | Contraceptive Devices |
| D004864 | Equipment and Supplies |
| D004338 | Drug Combinations |
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| Combined Oral Contraceptive | Drug | Use of combined oral contraceptive during the follow-up period |
|
| Progestin-only pills | Drug | Use of progestin-only pills during the follow-up period |
|
| Depot-Medroxyprogestereone Acetate | Drug | Use of depot-medroxyprogesterone acetato during the follow-up period |
|
| five years follow-up |
| triglycerides level | evaluation of variation of triglycerides serum levels during the usage of hormonal and non-hormonal contraceptives | five years follow-up |
| D044882 |
| Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D004364 | Pharmaceutical Preparations |
| D003276 | Contraceptives, Oral |
| D003271 | Contraceptive Agents, Female |
| D003270 | Contraceptive Agents |
| D012102 | Reproductive Control Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D045506 | Therapeutic Uses |
| D008525 | Medroxyprogesterone |
| D006908 | Hydroxyprogesterones |
| D011374 | Progesterone |
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |