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It is well known that sleep is essential for brain development and learning. Infants require extensive sleep for development of the hippocampus, pons, brainstem, and midbrain and for optimizing physical growth. It is also essential for brain plasticity; the genetically determined ability of the infant brain to change its structure and function in response to the environment. Studies in young animals have shown that sleep deprivation leads to increased programmed cell death, smaller brain size, and loss of brain plasticity, all of which have negative long-term impact on behaviour and learning ability.
Infant massage, a form of systematic tactile stimulation by human hands, improves sleep hygiene. Very little is known about how massage influences early brain development but it is certainly linked to the theory of environmental enrichment, which has been well established in animal models.
The aim of this project is to optimise the infant's sensory experience through a multi-sensory enrichment programme, including massage (a massage utilising a scented lotion before sleep each day), to encourage more structured sleep and ultimately show improved developmental and cognitive outcomes.
See study protocol attached.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interventional Arm- Baby Massage | Experimental | Interventional Arm= Baby Massage |
|
| Control Arm- no Baby Massage | No Intervention | Control Arm= no Baby Massage |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Baby Massage | Procedure | Structured massage of the baby |
|
| Measure | Description | Time Frame |
|---|---|---|
| Infant sleep measured by video EEG length of sleep cycles | Sleep EEG | assessment carried out in fourth month of life |
| Measure | Description | Time Frame |
|---|---|---|
| Neuro-development measured by Griffiths 3 Developmental Assessment | Griffiths 3 Developmental Assessment | Assessment carried out at 4 & 18 month of life |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Geraldine Boylan, PhD | INFANT UCC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cork University Maternity Hospital | Cork | Munster | Ireland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36944485 | Derived | O Sullivan MP, Livingstone V, Korotchikova I, Dempsey EM, Murray DM, Boylan GB. Reference centiles for infant sleep parameters from 4 to 16 weeks of age: findings from an Irish cohort. Arch Dis Child. 2023 Jun;108(6):481-485. doi: 10.1136/archdischild-2022-324016. Epub 2023 Mar 21. | |
| 34755881 | Derived | Ventura S, Mathieson SR, O'Toole JM, Livingstone V, Ryan MA, Boylan GB. Electroencephalographic sleep macrostructure and sleep spindles in early infancy. Sleep. 2022 Jan 11;45(1):zsab262. doi: 10.1093/sleep/zsab262. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jul 20, 2017 | Dec 11, 2017 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D065886 | Neurodevelopmental Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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single centre, unblinded, randomised, controlled study to evaluate whether a multi-sensory enrichment programme in the first 4 months of life will improve sleep architecture and neurodevelopment in healthy infants.
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Neurodevelopmental assessors are blinded to interventional arm.