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no stell cell accessed
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| Name | Class |
|---|---|
| Children's Hospital of Chongqing Medical University | OTHER |
| Chongqing Maternal and Child Health Hospital | OTHER |
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Very preterm infants are at high risk to develop to bronchopulmonary dysplasia (BPD) for the lack of effective measures to prevent or ameliorate this common and serious disorder. BPD remains a major cause of mortality and lifelong morbidity in preterm infants
Several studies have shown that transplantation of mesenchymal stem cells (MSCs) in immunocompetent animals attenuates lung injury, such as impaired alveolarization, inflammatory response, increased apoptosis, and fibrosis. Human umbilical cord blood (hUCB) is considered a better source of MSCs because of their ready availability and greater proliferative capacity and less antigenicity than other cell types.
transplantation of hUCB-derived MSCs should be effective in treating BPD. The safety and efficacy of MSC transplantation for prevention of BPD has not been tested previously, however.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| transplantation of mesenchymal stem cell | Experimental | transplantation of mesenchymal stem cell will be given to the infants with BPD. |
|
| no transplantation of mesenchymal stem cell | Active Comparator | transplantation of mesenchymal stem cell will be not given to the infants with BPD. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transplantation of mesenchymal stem cell | Drug | allogeneic human umbilical cord blood (hUCB)-derived mesenchymal stem cell (MSC) transplantation will be given to preterm infants |
|
| Measure | Description | Time Frame |
|---|---|---|
| death | the infant is dead due to lung disease | within two years |
| Measure | Description | Time Frame |
|---|---|---|
| Bayley Scales of Infant Development | scores of Bayley Scales of Infant Development at 2 months old and 2 years old | 30 months after birth |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University | Chongqing | Chongqing Municipality | 400042 | China |
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| ID | Term |
|---|---|
| D001997 | Bronchopulmonary Dysplasia |
| ID | Term |
|---|---|
| D055397 | Ventilator-Induced Lung Injury |
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| no transplantation of mesenchymal stem cell | Drug | MSC transplantation will be not given to preterm infants |
|
| D007235 |
| Infant, Premature, Diseases |
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |