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Previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery. However, the definition of the eosinophilic chronic rhinosinusitis is not very clear. Japanese researchers have designed a scoring system to diagnose eosinophilic chronic rhinosinusitis. In this study, the investigators hope to examine the practicability of this scoring system and have a better knowledge of eosinophilic chronic rhinosinusitis in china.The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.
The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| postoperational CRS | observe the symptoms and endoscopic appearance |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sinonasal outcome test-22 | Diagnostic Test | Evaluate the nasal mucosal inflammation condition and overall quality-of-life of CRS patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| nasal symptoms | presence of bothersome congestion or rhinorrhea or olfactory loss or headache.(VAS more than 7 points). | through study completion, an average of 2 year |
| endoscopic appearance indicate the uncontrol of CRS | The presence of diseased mucosa (nasal polyps, mucopurulent secretions,and/or inflamed mucosa) under endoscopy. (Lund-kennedy endoscopic score: Polyp≥1 or Oedema≥2 or Discharge≥2; 0-Absence of polyps;1-polyps in middle meatus only;2-polyps beyond middle meatus but not blocking the nose completely;3-polyps completely obstructing the nose. Oedema: 0-absent; 1-mild; 2-severe.Discharge: 0-no discharge; 1-clear, thin discharge; 2-thick, purulent discharge.) | through study completion, an average of 2 year |
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Inclusion Criteria:
Exclusion Criteria:
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Chronic rhinosinusitis patients after endoscopic surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jianbo Shi, doctor | Contact | 8602087333733 | shijb@mail.sysu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Jianbo Shi, doctor | Ent department, the first affiliated hospital, Sun Yat-sen University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the first affiliated hospital, Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | 510080 | China |
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| ID | Term |
|---|---|
| D012852 | Sinusitis |
| D009298 | Nasal Polyps |
| D004194 | Disease |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010254 | Paranasal Sinus Diseases |
| D009668 | Nose Diseases |
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The samples were abtained during endoscopic sinus surgery
| D012140 |
| Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D011127 | Polyps |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |