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This is a cross-sectional cohort study which aims to compare the invasive and non-invasive assessments on aortic blood pressure and cardiac funtion in subjects without history of cardio-vascular disease. Left ventricular (LV) filling pressure, LV volume, and aortic blood pressure will be measured invasively. Non-invasive assessment includes echocardiography,aortic, and carotid blood pressure measurement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All participants | Aortic blood pressure, LV filling pressrue, and LV volume will be measured in all participants. Meanwhile, echocardiography and non-invasive aortic blood presure measurement will be performed. Three devices will be used in non-invasive aortic blood presure measurement, including Sphygmocor (AtCor Medical, Australia), PulsePen (DiaTecne SRL, Italy), and Mobil-O-Graph (IEM, Germany). In conclusion, all participants will receive invasive and non-invasive left ventricular diastolic function assessment, together with invasive and non-invasive aortic blood pressure assessment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Invasive left ventricular diastolic function assessment | Diagnostic Test | Left ventricular (LV) polyethylene catheter was inserted into left ventricular to directly measure LV filling pressure. |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular filling pressure assessment with left heart catheterization | All participants will receive invasive left ventricular filling pressure assessment with left heart catheterization. | 1 day |
| Left ventricular diastolic function assessment with echocardiography using ASE recommendations | All participants will receive non-invasive left ventricular diastolic function assessment with echocardiography. The ASE-recommended (American Society of Echocardiography) creteria would be used to define left ventricular diastolic dysfunction. | 1 day |
| Left ventricular diastolic function assessment with echocardiography using EACVI recommendations | All participants will receive non-invasive left ventricular diastolic function assessment with echocardiography. The EACVI-recommended (European Association of Cardiovascular Imaging) creteria would be used to define left ventricular diastolic dysfunction. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Aortic blood presure obtained with Sphygmocor device | Sphygmocor device (AtCor Medical, Australia) will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual. | 1 day |
| Aortic blood presure obtained with PulsePen device |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with proposed coronary angiography and left left ventriculography but without diagnosed cardiovascular disease.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chen Chi, M.D. | Contact | 086-150-2178-7802 | chichen.david@gmail.com | |
| Yi Zhang, M.D., Ph.D. | Contact | 086-189-1768-6332 | yizshcn@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Yawei Xu, M.D., Ph.D. | Shanghai 10th People's Hospital | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27037982 | Background | Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner AD. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016 Apr;29(4):277-314. doi: 10.1016/j.echo.2016.01.011. No abstract available. | |
| 18579489 |
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| Invasive aortic blood pressure measurement | Diagnostic Test | Aortic blood pressure will be measured with polyethylene catheter in aortic root. |
|
| Non-Invasive left ventricular diastolic function assessment | Diagnostic Test | Echocardiography will be performed in all participants to assess left ventricular diastolic function non-invasively. |
|
| Non-Invasive aortic blood pressure measurement | Diagnostic Test | Three devices (Sphygmocor [AtCor Medical, Australia], PulsePen [DiaTecne SRL, Italy], and Mobil-O-Graph [IEM, Germany] ) will be used to assess aortic blood pressure non-invasively when participants are undergoing invasive aortic blood pressure measurement. |
|
PulsePen device (DiaTecne SRL, Italy) will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual. |
| 1 day |
| Aortic blood presure obtained with Mobil-O-Graph device | Mobil-O-Graph (IEM, Germany) device will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual. | 1 day |
| Aortic blood presure obtained with catheterization | Catheterization will be used in invasive aortic blood presure measurement. The cather will be placed in the aortic root while measuring the blood pressure. | 1 day |
| Background |
| Handoko ML, Paulus WJ. Polishing the diastolic dysfunction measurement stick. Eur J Echocardiogr. 2008 Sep;9(5):575-7. doi: 10.1093/ejechocard/jen181. Epub 2008 Jun 11. No abstract available. |
| 24459197 | Background | McEniery CM, Cockcroft JR, Roman MJ, Franklin SS, Wilkinson IB. Central blood pressure: current evidence and clinical importance. Eur Heart J. 2014 Jul;35(26):1719-25. doi: 10.1093/eurheartj/eht565. Epub 2014 Jan 23. |