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By bioelectrical impedance spectroscopy (BIS) association of fluid status in patients with valvular heart disease and cardiovascular outcome will be assessed.
Volume overload and abnormal fluid distribution are hallmarks in the syndromes of acute and chronic heart failure (HF) as well as valvular heart disease (VHD). Most patients, at some point in their disease progression, present acutely to an emergency department, where they will typically show symptoms of progressive volume overload.
Most patients respond well to standard diuretic therapy, usually at the costs of impaired renal function. Based on the assumption that clinically overt fluid overload is the result of progressive fluid accumulation, current European Society of Cardiology (ESC) and American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guidelines recommend a correction of volume status using diuretics, to reduce the total fluid volume. However there is no consensus on how to define fluid overload quantitavely.
In patients undergoing dialysis, bioelectrical impedance spectroscopy / body composition monitoring (BCM) is a well established tool to assess fluid status, allowing quantitative measurement.
This study aims to
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| median 1 |
| ||
| median 2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention | Other | no intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular outcome | composition of hospitalization due to heart failure and cardiovascular death | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Severity of valvular heart disease | BCM and association with valvular severity assessed using integrated approach to current guidelines for valvular heart disease | baseline |
| NT-proBNP | BCM and association with NT-proBNP |
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Inclusion Criteria:
Exclusion Criteria:
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Patients Valvular stenosis and/or regurgitation of all severities assessed by current recommendations are eligible for this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Andreas Kammerlander, MD | Contact | 004314040046140 | andreas.kammerlander@meduniwien.ac.at |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Recruiting | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D004487 | Edema |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| baseline |
| Clinical status (NYHA functional class) | BCM and association with NYHA functional class | baseline |
| Renal impairment | BCM and association with renal impariment (eGFR) | baseline |