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Double lumen tube (DLT) needs to be intubated to isolate ventilations of left and right lungs for thoracic surgery. Post-operative sore throat and hoarseness are more frequent with DLT intubation than with single one. Which is may because DLT is relatively thicker, harder, sideway curved and therefore more likely to damage the vocal cord or trachea during intubation, and advanced deeper to the carina and main bronchus level. In the conventional method of intubation, DLT is rotated 90 degrees and advanced blindly to the main bronchus level after DLT is intubated through vocal cord using the direct laryngoscopy. After the blind advancement, the sufficient tube position needs to be gained and confirmed with the fiberoptic bronchoscope. In the bronchoscope guide method, after DLT is intubated through vocal cord using the direct laryngoscopy, the pathway into the targeted main bronchus is secured using the fiberoptic bronchoscope which is passed through a bronchial lumen of DLT. And then DLT can be advanced through the guide of the bronchoscope. In this study, we intend to compare post-operative sore throat, hoarseness and airway injury between the two methods. We hypothesize that the bronchoscope guide method can reduce the post-operative complications and airway injury because surrounding tissues of the airway can be less irritated by DLT intubation in the guide method than in a conventional.
For a constant guide effect, we use fiberoptic bronchoscopes with same outer diameter (4.1 mm) which can pass through a bronchial lumen of 37 and 39 Fr Lt. DLT and cannot pass through 35 Fr or smaller Lt. DLTs.
<Lt. DLT size selection>
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bronchoscope guide group | Experimental | DLT is advanced into the main bronchus through the guide of fiberoptic bronchoscope (Bronchoscope guided advancement). |
|
| Conventional group | Active Comparator | DLT is advanced blindly to the main bronchus level (Conventional advancement). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bronchoscope guided advancement | Procedure | During the anesthetic induction for thoracic surgery, Lt. DLT is intubated using the bronchoscope-guided method. The method is as follows.
|
| Measure | Description | Time Frame |
|---|---|---|
| Post-operative sore throat (24 h) | The degree of throat pain (Visual Analogue Scale (VAS); 0, no pain; 10, most | 24 hour after tracheal extubation |
| Measure | Description | Time Frame |
|---|---|---|
| Resistance against DLT passage through vocal cord | none/mild/severe | Intraoperative |
| Resistance against DLT advancement | none/mild/severe |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jin-Woo Park, MD | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7880666 | Background | Christensen AM, Willemoes-Larsen H, Lundby L, Jakobsen KB. Postoperative throat complaints after tracheal intubation. Br J Anaesth. 1994 Dec;73(6):786-7. doi: 10.1093/bja/73.6.786. | |
| 10995141 | Background | McHardy FE, Chung F. Postoperative sore throat: cause, prevention and treatment. Anaesthesia. 1999 May;54(5):444-53. doi: 10.1046/j.1365-2044.1999.00780.x. |
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|
| Conventional advancement | Procedure | During the anesthetic induction for thoracic surgery, Lt. DLT is intubated using the conventional method. The method is as follows.
|
|
| Intraoperative |
| Intubation time | stop of initial mask ventilation - intubation through vocal cord | Intraoperative |
| The number of attempts for intubation | The number of attempts for intubation through vocal cord | Intraoperative |
| The number of right misplacement of Lt. DLT | The number of right misplacement of Lt. DLT confirmed using the fiberoptic bronchoscope after the advancement | Intraoperative |
| Time for DLT positioning: stop of initial mask ventilation - success of the 1st fine DLT positioning | Time for DLT positioning: stop of initial mask ventilation - success of the 1st fine DLT positioning into Lt. main bronchus | Intraoperative |
| Heart rate | Heart rate Just before Lt. DLT intubation / 2 min after success of the 1st fine DLT positioning | Intraoperative |
| Mean arterial pressure | Mean arterial pressure Just before Lt. DLT intubation / 2 min after success of the 1st fine DLT positioning | Intraoperative |
| IV PCA | Fentanyl usage with PCA | At 24 hours after the extubation |
| Airway injury (Lt. main bronhcus, carina, trachea) | When spontaneous breathing of the patient starts after the thoracic surgery | Intraoperative |
| Airway injury (vocal cord) | When spontaneous breathing of the patient starts after the thoracic surgery | Intraoperative |
| Post-operative sore throat (1 h) | The degree of throat pain (Visual Analogue Scale (VAS); 0, no pain; 10, most pain) after tracheal extubation | 24 hours after tracheal extubation |
| Post-operative hoarseness (1 h) | The incidence of hoarseness after tracheal extubation | 1 hour after tracheal extubation |
| Post-operative hoarseness (24 h) | The incidence of hoarseness after tracheal extubation | 24 hour after tracheal extubation |
| Oral dryness | The incidence of oral dryness | 24 hours after tracheal extubation |
| Dysphagia | The incidence of dysphagia | 24 hours after tracheal extubation |
| 26149601 | Background | Chang JE, Min SW, Kim CS, Han SH, Kwon YS, Hwang JY. Effect of prophylactic benzydamine hydrochloride on postoperative sore throat and hoarseness after tracheal intubation using a double-lumen endobronchial tube: a randomized controlled trial. Can J Anaesth. 2015 Oct;62(10):1097-103. doi: 10.1007/s12630-015-0432-x. Epub 2015 Jul 7. |
| 19020122 | Background | Park SH, Han SH, Do SH, Kim JW, Rhee KY, Kim JH. Prophylactic dexamethasone decreases the incidence of sore throat and hoarseness after tracheal extubation with a double-lumen endobronchial tube. Anesth Analg. 2008 Dec;107(6):1814-8. doi: 10.1213/ane.0b013e318185d093. |
| 26787799 | Result | Seo JH, Cho CW, Hong DM, Jeon Y, Bahk JH. The effects of thermal softening of double-lumen endobronchial tubes on postoperative sore throat, hoarseness and vocal cord injuries: a prospective double-blind randomized trial. Br J Anaesth. 2016 Feb;116(2):282-8. doi: 10.1093/bja/aev414. |
| 10562789 | Result | Cheong KF, Koh KF. Placement of left-sided double-lumen endobronchial tubes: comparison of clinical and fibreoptic-guided placement. Br J Anaesth. 1999 Jun;82(6):920-1. doi: 10.1093/bja/82.6.920. |
| 16931978 | Result | Knoll H, Ziegeler S, Schreiber JU, Buchinger H, Bialas P, Semyonov K, Graeter T, Mencke T. Airway injuries after one-lung ventilation: a comparison between double-lumen tube and endobronchial blocker: a randomized, prospective, controlled trial. Anesthesiology. 2006 Sep;105(3):471-7. doi: 10.1097/00000542-200609000-00009. |
| 32332265 | Derived | Park JW, Jo JH, Park JH, Bae YK, Park SJ, Cho SW, Han SH, Kim JH. Comparison of conventional and fibreoptic-guided advance of left-sided double-lumen tube during endobronchial intubation: A randomised controlled trial. Eur J Anaesthesiol. 2020 Jun;37(6):466-473. doi: 10.1097/EJA.0000000000001216. |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010612 | Pharyngitis |
| D006685 | Hoarseness |
| D017695 | Soft Tissue Injuries |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D014832 | Voice Disorders |
| D007818 | Laryngeal Diseases |
| D012120 | Respiration Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D012818 | Signs and Symptoms, Respiratory |
| D014947 | Wounds and Injuries |
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