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The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal weight | nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI < 25 kg/m2, n=349) |
| |
| Overweight | nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI < 30 kg/m2, n=154) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rs662799 (APOA5 -1131T>C) | Genetic | Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. |
| Measure | Description | Time Frame |
|---|---|---|
| Brachial-ankle PWV (baPWV) | cm/s | at baseline |
| Brachial-ankle PWV (baPWV) | cm/s | 3-year follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Triglyceride | mg/dL | at baseline |
| Triglyceride | mg/dL | 3-year follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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We performed a 3-year prospective cohort study that included 800 heathy subjects (30-65 years old), of these, 503 nondiabetic and nonobese individuals were finally selected.
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| Name | Affiliation | Role |
|---|---|---|
| Jong Ho Lee, PhD | Dept. of Food and Nutrition, Colleage of Human Ecology, Yonsei University | Principal Investigator |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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|
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |