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Cannabis use can lead to addiction in about 5 to 10 % of users in France. Currently, behavioral interventions are the most dependable but effectiveness is still reduced. Mindfulness meditation has demonstrated an effectiveness in several meta analysis (anxiety and depressive disorder) and seems to be relevant to reduce anxious and impulsive symptoms found in cannabis use disorders.
This study proposes to determinate the mindfulness effectiveness in reduction of cannabis use in regular consumer. The consumption decrease is estimated with a retrospective diary, TLFB (Timeline Follow Back) which collect cannabis use every week until the 12th. Urine (week 0/baseline, 2, 4, 6, 8, 10, 12) and hair (week 0/baseline, 10) analyses are regularly effected.
Patients included in control group get classic cares in an addictology center in CHRU of Nancy. Patients included in mindfulness group receive one session a week during eight weeks (MBRP protocol : Mindfulness -Based Relapse Prevention). The study process goes on for 12 weeks.
An ancillary study measures the impact of cannabis decreases on retinal electrophysiological and architectural markers, usually disturbed by cannabis uses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MBRP group | Experimental | 20 patients 2 groups of 10 patients |
|
| classic care in addictology center | Active Comparator | 20 patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mindfulness based relapse prevention (MBRP) | Behavioral | These weekly visits include a Mindfulness Meditation session: The sessions of meditation take place in a dedicated room. The collective sessions owed approximately of 2 hours and will approach the following themes: (1) Autopilot, (2) Facing obstacles, (3) Full awareness of breath, (4) Staying present, (5) Allow, let go (6) Thoughts are not facts, (7) How to take care of oneself, (8) Mindfulness on a daily basis. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cannabis use between the baseline and the 8th week of treatment | The number of days of cannabis use (addition weeks 7 and 8) will be compared to the " less than or equal to 4 days"target. | At baseline, weeks 7 and 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients who stopped cannabis 2 weeks after 8 weeks of treatment | measured by the absence of THC and metabolites in urinary and hair samples and the absence of cannabis use mentioned in the Timeline Follow Back retrospective diary (TLFB) | at week 10 |
| Patient retention rate at the end of treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vincent Laprevote | Contact | 03 83 92 84 40 | Vincent.LAPREVOTE@cpn-laxou.com | |
| Thomas Schwitzer | Contact | 03 83 92 84 40 | thomas.schwitzer@univ-lorraine.fr |
| Name | Affiliation | Role |
|---|---|---|
| Vincent Laprevote | Centre Psychothérapique de Nancy | Principal Investigator |
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| ID | Term |
|---|---|
| D016739 | Behavior, Addictive |
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D003192 | Compulsive Behavior |
| D007175 | Impulsive Behavior |
| D001519 | Behavior |
| D019966 | Substance-Related Disorders |
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|
| classic therapy | Behavioral | These weekly visits include usual addiction care provided during a consultation. This care includes psychotherapeutic management: brief interventions, cognitive-behavioral therapies, motivational interviews; associated with nonsystematic pharmacological management. |
|
number of patients who continue study until week 8 |
| at week 8 |
| Severity of withdrawal symptoms questionnaire | measured by the Cannabis Withdrawal Scale (CWS) | At week 2, 4, 6, 8, 10, 12 |
| ERG : electroretinogram. | measures a and b on ERG flash Measures P50 and N95 on ERG pattern | week 0, 8, 12 |
| Thickness of retinal structure | measured by Optical Coherence Tomography (OCT) | at week 0 and 12 |
| D064419 |
| Chemically-Induced Disorders |
| D001523 | Mental Disorders |