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| Name | Class |
|---|---|
| Lorestan University of Medical Sciences | OTHER |
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In this observational case-control study investigators aimed to assess the serum levels of adipokines such as Apelin, Chemerin and adiponectin in patients with irritable bowel syndrome (IBS), and compare it with healthy controls. Furthermore, investigators evaluated the possible correlation of these adipokines with IBS-QoL, IBSSS, GI symptoms and other clinical and psychological disorders.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case | patients with irritable bowel syndrome | ||
| Control | Healthy subjects without any gastrointestinal disorders, chronic diseases and malignancy. |
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| Measure | Description | Time Frame |
|---|---|---|
| Serum levels of Apelin, Chemerin and adiponectin | in recruitment |
| Measure | Description | Time Frame |
|---|---|---|
| IBS-Quality of life (IBS-QoL) | The Quality of life was assessed at the baseline and at the end of the study using a self-report QoL measure specific to IBS (IBS-QoL) with 34 items | in recruitment |
| IBS severity score system (IBSSS) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients were recruited from the outpatient clinic at the Lorestan University of Medical Sciences, Khorramabad, Iran, by an attendant gastroenterologist.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lorestan university of medical sciences | Khorramabad | Iran |
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| ID | Term |
|---|---|
| D043183 | Irritable Bowel Syndrome |
| ID | Term |
|---|---|
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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Irritable bowel syndrome severity score system is validated for use in IBS patients, which included five clinically relevant items during a 10-day period: (i) severity of abdominal pain, (ii) frequency of abdominal pain, (iii) severity of abdominal distention or tightness, (iv) dissatisfaction with bowel habits, and (v) interference of IBS with life in general. Each item was scored on a scale from 0 to 100, and the sum of these five items was the score of IBS severity (range 0-500). Scores of 75-175, 175-300, and >300 indicated mild, moderate, and severe cases, respectively.
| in recruitment |
| Gastrointestinal symptoms | in recruitment |
| Somatic Symptom | in recruitment |
| Personality | Big Five Inventory Questionnaire | in recruitment |
| Perceived Stress Scale | The Perceived Stress Scale (PSS) is the most widely used psychological instrument for measuring the perception of stress. It is a measure of the degree to which situations in one's life are appraised as stressful.Higher PSS scores were associated with a greater vulnerability to stressful life-event-elicited depressive symptoms. PSS scores are obtained by reversing responses (e.g., 0 = 4, 1 = 3, 2 = 2, 3 = 1 & 4 = 0) to the four positively stated items (items 4, 5, 7, & 8) and then summing across all scale items. A short 4 item scale can be made from questions 2, 4, 5 and 10 of the PSS 10 item scale. | in recruitment |
| D004066 | Digestive System Diseases |