Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing.
In this study, patients who presented with non-traumatic anterior epistaxis to emergency departments will be included in this study. Three different therapy option are created; first, nasal compression with tranexamic acid, second, simple nasal compression without any drugs. And third, packing with Merocel.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tranexamic acid group | Active Comparator | 500mg tranexamic acid is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually. |
|
| Placebo group | Placebo Comparator | 5ml normal saline is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually. |
|
| Merocel Group | Active Comparator | Merocel packing is applied. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic Acid | Drug | 500mg tranexamic acid is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Success rate of interventions to stop bleeding | Percentages of numbers of patients who have stopped bleeding within first 15 minutes after nasal compression or Merocel packing | First 15 minutes |
| Numbers of patients who needs rescue treatment | In patients who have unstoppable epistaxis within 15 minutes, Merocel packing will be applied as a rescue treatment. Numbers of these patients will be recorded. | After 15 minutes first intervention method. |
| Measure | Description | Time Frame |
|---|---|---|
| Re-bleeding | Frequency of re-bleeding within first 24 hours. | 24 hour |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Keçiören Training and Research Hospital | Ankara | 06000 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31080025 | Derived | Akkan S, Corbacioglu SK, Aytar H, Emektar E, Dagar S, Cevik Y. Evaluating Effectiveness of Nasal Compression With Tranexamic Acid Compared With Simple Nasal Compression and Merocel Packing: A Randomized Controlled Trial. Ann Emerg Med. 2019 Jul;74(1):72-78. doi: 10.1016/j.annemergmed.2019.03.030. Epub 2019 May 9. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D004844 | Epistaxis |
| ID | Term |
|---|---|
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D006470 | Hemorrhage |
Not provided
Not provided
| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Normal saline | Drug | 5 cc normal saline is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually. |
|
| Merocel | Device | Merocel packing is applied. |
|
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D000077324 |
| Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |