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To evaluate the effect of performing laparoscopic ovarian drilling (LOD) before proceeding to in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) on the cycle outcomes in polycystic ovarian syndrome (PCOS) patients with high antimullerian hormone (AMH) levels
Retrospective case-control study of PCOS women with high serum AMH level (≥ 7 ng/ml) who were subjected IVF/ICSI. Women underwent LOD in the preceding 3 months prior to IVF/ICSI (study group) will be compared with a control group of women who did not underwent LOD (control group)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | PCOS women with AMH level (≥ 7 ng/ml) who underwent LOD in the preceding 3 months prior to IVF/ICSI |
| |
| Control group | PCOS women with AMH level (≥ 7 ng/ml) who did not undergo LOD in the preceding 3 months prior to IVF/ICSI |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LOD | Procedure | Women underwent LOD in the preceding 3 months prior to IVF/ICSI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of oocytes retrieved | Number of collected oocytes during oocyte retrieval | 36-38 hours after triggering of oocyte maturation |
| Oocyte maturity rate | Calculated for each woman by dividing the number of mature oocytes (MII oocytes) by the total number of oocytes retrieved | Within one hour after oocyte retrieval |
| Fertilization rate | Calculated for each couple by dividing the number of fertilized oocytes by the number of injected (or inseminated) oocytes | 20-24 hours after injection (or insemination) |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after the ET) divided by the number of ET procedures | 6 weeks after embryo transfer |
| Implantation rate |
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Inclusion Criteria:
Exclusion Criteria:
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Fertility care clinic
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| Name | Affiliation | Role |
|---|---|---|
| Mohamed S Abdelhafez, Dr | Mansoura University | Principal Investigator |
| Alaa Wageh, Dr | Mansoura University | Study Director |
| Waleed El-refaie, Dr | Mansoura University | Study Director |
| Maher Shams, Dr | Mansoura University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility Care Unit (FCU) in Mansoura University Hospital | Al Mansurah | Dakahlia Governorate | 35111 | Egypt |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
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Number of gestational sacs on TVS scan at 4-6 weeks after ET divided by the number of transferred embryos |
| 6 weeks after embryo transfer |
| Incidence of early OHSS | Incidence of OHSS within 9 days of final triggering of oocyte maturation | Within 9 days of final triggering of oocyte maturation |
| D009369 |
| Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |