Tacrolimus 0.03% ointment twice daily for 6 months

hydrocortisone acetate 1% ointment twice daily for 6 months

topical tacrolimus 0.03% twice daily for 6 months

• The percentage of vitiligo involvement for each body region is calculated by using the palmar method. The palmar method uses the palmar surface area of the patient's hand as an estimation guide and defines the surface of the patient's hand including fingers to be 1% of the total body surface area.
• The extent of residual depigmentation is expressed by the following percentages: 0, 10%, 25%, 50%, 75%, 90%, or 100%.
• At 100% depigmentation, no pigment is present; at 90%, specks of pigment are present; at 75%, the depigmented area exceeds the pigmented area; at 50%, the depigmented and pigmented areas are equal; at 25%, the pigmented area exceeds the depigmented area; at 10%, only specks of depigmentation are present.
• VASI= ∑ [HAND UNITS] × [RESIDUAL DEPIGMENTATION].

): is a six-point scale for evaluating vitiligo activity.

• In this score grading is based on disease activity and time period. Grading is as follows: + 4: (activity lasting 6 weeks or less); score +3: (activity lasting 6 weeks to 3 months); score 2: (activity lasting 3-6 months); score1: (activity lasting 6-12 months); score 0: (stable for 1 year or more); score -1: (stable with spontaneous repigmentation for 1 year or more).
• A low Vitiligo disease activity score indicate less vitiligo activity.