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Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. For patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. In this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nasal dexmedetomidine | Experimental | dexmedetomidine is given nasally, saline is given intravenously |
|
| intravenous dexmedetomidine | Experimental | saline is given nasally, dexmedetomidine is given intravenously |
|
| normal saline | Placebo Comparator | saline is given nasally and intravenously |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intravenous dexmedetomidine | Drug | drug is intravenously infused to patients |
| |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of coughing | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Ricker's agitation-sedation score | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes | |
| score of coughing | 0=no coughing;1=intermittent coughing;2=continuous coughing |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lize Xiong | Air Force Military Medical University, China | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xijing Hospital | Xi'an | Shaanxi | 710032 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24974190 | Result | Peng K, Wu S, Liu H, Ji F. Dexmedetomidine as an anesthetic adjuvant for intracranial procedures: meta-analysis of randomized controlled trials. J Clin Neurosci. 2014 Nov;21(11):1951-8. doi: 10.1016/j.jocn.2014.02.023. Epub 2014 Jun 25. | |
| 21991729 | Result | Soliman RN, Hassan AR, Rashwan AM, Omar AM. Prospective, randomized controlled study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anesthesia. Middle East J Anaesthesiol. 2011 Feb;21(1):23-33. |
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| ID | Term |
|---|---|
| D002532 | Intracranial Aneurysm |
| ID | Term |
|---|---|
| D020765 | Intracranial Arterial Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| nasal dexmedetomidine |
| Drug |
drug is nasally given to patients |
|
| intravenous saline | Drug | saline is given to patients intravenously |
|
| nasal saline | Drug | normal saline is given to patients nasally |
|
| from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes |
| time to response to verbal command | from end of infusing anesthetics to response to verbal command,averagely 20 minutes |
| time to extubation | from end of infusing anesthetics to extubation,averagely 28 minutes |
| blood pressure before and after extubation | from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes |
| blood glucose before and after aneurysm embolism | immediately before inserting coil and after finishing inserting coil,an average of 1 hour |
| blood lactate before and after aneurysm embolism | immediately before inserting coil and after finishing inserting coil,,an average of 1 hour |
| Mini-mental state examination score | 24 hours after surgery |
| 28631453 | Result | Elbakry AE, Ibrahim E. Propofol-dexmedetomidine versus propofol-remifentanil conscious sedation for awake craniotomy during epilepsy surgery. Minerva Anestesiol. 2017 Dec;83(12):1248-1254. doi: 10.23736/S0375-9393.17.11873-0. Epub 2017 Jun 14. |
| 28639236 | Result | Jun JH, Kim KN, Kim JY, Song SM. The effects of intranasal dexmedetomidine premedication in children: a systematic review and meta-analysis. Can J Anaesth. 2017 Sep;64(9):947-961. doi: 10.1007/s12630-017-0917-x. Epub 2017 Jun 21. |
| 28470100 | Result | Sun Y, Li Y, Sun Y, Wang X, Ye H, Yuan X. Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study. J Int Med Res. 2017 Jun;45(3):973-983. doi: 10.1177/0300060517699467. Epub 2017 Mar 21. |
| D009422 | Nervous System Diseases |
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D017670 |
| Sodium Compounds |