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| Name | Class |
|---|---|
| University of Medicine and Pharmacy "Victor Babes" Timisoara | OTHER |
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Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population
The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the "Louis Turcanu" Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MetS+ | Obese group with metabolic syndrome/Data processing from Patient Medical Files |
| |
| MetS- | Obese group without metabolic syndrome/Data processing from Patient Medical Files |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MetS+ | Other | Data processing from Patient Medical Files |
| |
| MetS- |
| Measure | Description | Time Frame |
|---|---|---|
| Defining obesity in the pediatric population | Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph. | Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile. |
| Leptin changes in the obese children with metabolic syndrome | Evaluating leptin in the obese group with metabolic syndrome | Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml. |
| Adiponectin changes in the obese children with metabolic syndrome | Evaluating adiponectin in the obese group with metabolic syndrome | Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values. |
| Assessing cardiovascular risk in the obese children with metabolic syndrome | Evaluating hsCRP in the obese group with metabolic syndrome | hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l |
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Inclusion Criteria:
Exclusion Criteria:
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All children admitted to the Endocrinology, Diabetology and Cardiology Department who met the Inclusion Criteria
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| Name | Affiliation | Role |
|---|---|---|
| Alexandru Florin Rogobete, PhDS | Romanian Society of Anesthesia and Intensive Care | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28890432 | Background | Beyazit F, Unsal MA. Obesity and insulin resistance are significant predictors of serum leptin levels. J Turk Ger Gynecol Assoc. 2017 Sep 1;18(3):158-159. doi: 10.4274/jtgga.2017.0027. No abstract available. | |
| 28886308 | Background | Lopez-Quintero A, Garcia-Zapien AG, Flores-Martinez SE, Diaz-Burke Y, Gonzalez-Sandoval CE, Lopez-Roa RI, Medina-Diaz E, Munoz-Almaguer ML, Sanchez-Corona J. Contribution of polymorphisms in the LEP, LEPR and RETN genes on serum leptin and resistin levels in young adults from Mexico. Cell Mol Biol (Noisy-le-grand). 2017 Aug 30;63(8):10-18. doi: 10.14715/cmb/2017.63.8.3. |
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| ID | Term |
|---|---|
| D000067329 | Obesity, Metabolically Benign |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| Other |
Data processing from Patient Medical Files |
|
| 28882065 | Background | Bagherniya M, Khayyatzadeh SS, Heidari Bakavoli AR, Ferns GA, Ebrahimi M, Safarian M, Nematy M, Ghayour-Mobarhan M. Serum high-sensitive C-reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study. Ann Clin Biochem. 2018 Jul;55(4):422-429. doi: 10.1177/0004563217733286. Epub 2017 Nov 23. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |