Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate the impact of follicular flushing on fertilization rate in women undergoing IVF treatment
This will be a prospective observational study on the effect of follicular flushing on fertilization rate in women undergoing IVF treatment.
Oocytes from each woman will be allocated to one of three groups, depending on the aspirate or flush they are recovered from:
Group I= egg retrieved in the follicular fluid of the first aspirate (no flushing) Group II= egg retrieved in the 1st-2nd flush Group III= egg retrieved in the 3rd-5th flush
development and utilization. Pregnancy rates will be reported as a surrogate outcome.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I | Group I= egg retrieved in the follicular fluid of the first aspirate (no flushing) |
| |
| Group II | Group II= egg retrieved in the 1st-2nd flush |
| |
| Group III | Group III= egg retrieved in the 3rd-5th flush |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intracytoplasmic sperm injection (ICSI) | Procedure | All eggs will be fertilized by ICSI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fertilization rate | Number of fertilized eggs per oocyte retrieved | Day 1 post oocyte retrieval |
| Measure | Description | Time Frame |
|---|---|---|
| Maturation rate | Number of mature (MII) eggs per oocyte retrieved | Day of oocyte retrieval |
| Good quality embryos | Number of good quality embryos on Day 2 |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Women undergoing IVF treatment
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tryfon G Lainas, PhD | Contact | 00302107236333 | tlainas@eugonia.com.gr | |
| George T Lainas, MD | Contact | 00302107236333 | ggslns@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Tryfon G Lainas, Phd | Eugonia | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eugonia | Recruiting | Athens | 11528 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28333185 | Background | von Horn K, Depenbusch M, Schultze-Mosgau A, Griesinger G. Randomized, open trial comparing a modified double-lumen needle follicular flushing system with a single-lumen aspiration needle in IVF patients with poor ovarian response. Hum Reprod. 2017 Apr 1;32(4):832-835. doi: 10.1093/humrep/dex019. | |
| 28276189 | Background |
Not provided
Not provided
undecided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D020554 | Sperm Injections, Intracytoplasmic |
| ID | Term |
|---|---|
| D005307 | Fertilization in Vitro |
| D027724 | Reproductive Techniques, Assisted |
| D012099 | Reproductive Techniques |
| D013812 | Therapeutics |
Not provided
Not provided
Not provided
Not provided
Not provided
| Day 2 post oocyte retrieval |
| Blastocyst formation rate | Number of blastocysts on Day 5 per fertilized egg | Day 5 post oocyte retrieval |
| Franasiak JM. Follicular flushing: time to look elsewhere to improve in vitro fertilisation outcomes? BJOG. 2017 Jul;124(8):1197. doi: 10.1111/1471-0528.14628. No abstract available. |
| 23065177 | Background | Roque M, Sampaio M, Geber S. Follicular flushing during oocyte retrieval: a systematic review and meta-analysis. J Assist Reprod Genet. 2012 Nov;29(11):1249-54. doi: 10.1007/s10815-012-9869-9. Epub 2012 Oct 13. |
| D008919 | Investigative Techniques |