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Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma wipplei on a genetic predisposition which should be considered in patients with recurrent episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and epithelioid granuloma.
Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia.
None of theses findings is specific and most patients have arthritis or low back pain mimicking rheumatoid arthritis and spondyloarthritis.
As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma whipplei is low in this context.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Classic Whipple's disease (CWD) | Classic Whipple's disease (CWD), defined as
| ||
| Focal Whipple's disease (FWD) | Focal Whipple's disease (FWD), defined as
| ||
| Chronic T. whipplei-associated arthritis (CTWA) | Chronic T. whipplei-associated arthritis (CTWA) defined as chronic arthritis and
|
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| Measure | Description | Time Frame |
|---|---|---|
| Number of patients diagnosed as whipple's disease | Diagnosis of Whipple's disease based on
| Day 0 ( Date of diagnostic) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of test performed in each centre | Number of diagnoses according to tests Patients will be divided into three groups Classic Whipple's disease (CWD), defined as :
Focal Whipple's disease (FWD)
Chronic T. whipplei-associated arthritis (CTWA): chronic arthritis and
|
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Inclusion Criteria:
Exclusion Criteria:
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Patients with a diagnosis whipple's disease
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU d'ANGERS | Angers | 49933 | France | |||
| CHRU de Brest |
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| ID | Term |
|---|---|
| D008061 | Whipple Disease |
| ID | Term |
|---|---|
| D000196 | Actinomycosis |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
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| Day 0 (Date of diagnostic) |
| Brest |
| 29609 |
| France |
| CH le MAns | Le Mans | 72037 | France |
| CHU de Nantes | Nantes | 44093 | France |
| CH d'ORLEANS | Orléans | 450000 | France |
| CHU de POITIERS | Poitiers | 86 021 | France |
| CHU de Rennes | Rennes | 35000 | France |
| CHU de Tours | Tours | 37044 | France |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D008286 | Malabsorption Syndromes |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |