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In the study the investigators aim to test whether transcranial direct current stimulation (tDCS)-induced pain reduction is in association with functional changes in the brain measured with functional magnetic resonance imaging (fMRI) in patients with chronic inflammatory bowel diseases (IBD).
Hypothesis: Transcranial direct current stimulation can reduce the perception of pain in patients with chronic inflammatory bowel diseases, which is in association with changes in the brain measured via fMRI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active tDCS | Active Comparator | Active transcranial direct current stimulation |
|
| Sham tDCS | Sham Comparator | Sham transcranial direct current stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial direct current stimulation | Device | Device: Transcranial direct current stimulation Transcranial direct current stimulation over the motor cortex. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Functional and/or structural changes in the brain measured with cerebral MRI | Participants will be followed for 2 weeks | 2 week |
| Changes in pain measured with visual analogue scale | Participants will be followed for 2 weeks | 2 weeks |
| Changes in perception of pain measured with an algometer (pain pressure threshold) | Participants will be followed for 2 weeks | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in questionnaire "quality of life" | questionnaire | 2 weeks |
| Changes in functional symptoms | Questionnarie: irritable bowel syndrome - severity scoring system (IBS-SSS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Magdalena S Prüß-Volz, MD | Contact | +493084452718 | magdalena.pruess@charite.de |
| Name | Affiliation | Role |
|---|---|---|
| Magdalena S Prüß-Volz, MD | Charite University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité University Medicine | Recruiting | Berlin | 12200 | Germany |
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|
| 2 weeks |
| Changes in activity indices | Harvey-Bradshaw Index (HBI) or simple clinical colitis activity index | 2 weeks |
| Changes in pain catastophizing scale | 2 weeks |
| Changes in inflammation biomarker (blood - C-reactive protein) | 2 weeks |
| Changes in inflammation biomarker (stool - calprotectin) | 2 weeks |
| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
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