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Pulmonary homografts are standard substitutes for right ventricular outflow tract reconstruction in congenital heart surgery. Unfortunately shortage and conduit failure secondary to early calcifications and shrinking are observed particularly for small sized conduits in younger patients. In neonates, Contegra® 12mm could be a valuable alternative, but conflicting evidence exists. This retrospective study compared the outcome of these two conduits in a newborn population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Contegra patients |
| ||
| Pulmonary homograft patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| right ventricular outflow tract reconstruction with contegra | Procedure | Contegra pulmonary valved conduit is an animal jugular vein that contains a valve with three leaflets that are similar to a human heart valve. |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of mid term course between pediatric right ventricular outflow tract recontruction with homograft and contegra | up to 195 months post right ventricular outflow tract recontruction |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of early conduit-related reintervention according to the Nakata index | up to 195 months post right ventricular outflow tract recontruction | |
| Proportion of early conduit-related reintervention according to the congenital heart defect diagnosis |
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Inclusion Criteria:
neonatal patients who had a reconstruction of the right ventricular outflow tract with a pulmonary homograft or a Contegra between January 1992 and December 2014 at HUDERF
Exclusion Criteria:
NA
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All patients who underwent a right ventricular outflow tract reconstruction between January 1992 and December 2014 at the Hôpital Universitaire des Enfants Reine Fabiola, Belgium
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| Name | Affiliation | Role |
|---|---|---|
| Pierre Wauthy, MDPhD | Queen Fabiola Children's University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Universitaire Des Enfants Reine Fabiola | Brussels | 1020 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30942148 | Derived | Falchetti A, Demanet H, Dessy H, Melot C, Pierrakos C, Wauthy P. Contegra versus pulmonary homograft for right ventricular outflow tract reconstruction in newborns. Cardiol Young. 2019 Apr;29(4):505-510. doi: 10.1017/S1047951119000143. Epub 2019 Apr 3. |
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| right ventricular outflow tract reconstruction with pulmonary homograft | Procedure | cryopreserved pulmonary homografts |
|
| up to 195 months post right ventricular outflow tract recontruction |
| Proportion of early conduit-related reintervention in right ventricular outflow tract recontructed with contegra | up to 195 months post right ventricular outflow tract recontruction |
| Proportion of early conduit-related reintervention in right ventricular outflow tract recontructed with pulmonary homograft | up to 195 months post right ventricular outflow tract recontruction |
| Overal mortality in right ventricular outflow tract recontructed with contegra | up to 195 months post right ventricular outflow tract recontruction |
| Overal mortality in right ventricular outflow tract recontructed with pulmonary homograft | up to 195 months post right ventricular outflow tract recontruction |
| Residual pulmonary arterial hypertension rate in right ventricular outflow tract recontructed with contegra | up to 195 months post right ventricular outflow tract recontruction |
| Residual pulmonary arterial hypertension rate in right ventricular outflow tract recontructed with pulmonary homograft | up to 195 months post right ventricular outflow tract recontruction |
| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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