The Effects of Ethanol on Intestinal Permeability and Gut Hormones

The Effects of Orally Ethanol vs. Isoethanolaemic i.v. Infusion of Ethanol on Intestinal Permeability and Gut Hormones

The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.

Inclusion Criteria:

• Caucasian male between 20 and 50 years of age
• Body mass index (BMI) between 19 and 25 kg/m2
• Weekly alcohol intake of less than 14 units of alcohol (of 12 g)
• Normal fasting plasma glucose concentration (i.e. <6 mmol/l) and normal glycated haemoglobin A1c (HbA1c) (i.e. ≤42 mmol/mol)
• Normal haemoglobin
• Informed consent

Exclusion Criteria:

• First-degree relatives with diabetes and/or liver disease
• Liver disease or other alcohol-related diseases, diabetes mellitus
• Liver disease (serum ALAT and/or serum ASAT >2 × normal values)
• Nephropathy (serum creatinine above normal range and/or albuminuria)