The main objective of this study is to assess the efficacy of bilateral deep brain stimulation (DBS) of the Nucleus Accumbens(NAc) as a novel treatment in severe methamphetamine addiction. Our hypothesis is that bilateral DBS of the NAc will significantly reduce the craving for methamphetamine.

Inclusion Criteria:

• DSM-IV-TR diagnosis of Drug addiction disorder;
• Age 18-65 years old;
• Proficiency in Mandarin language;
• Failure to detox more than three times;
• Capacity to provide informed consent (understanding of the study purpose and methods);

Exclusion Criteria:

• Multidrug abuse and formation of addiction;
• Serious and unstable organic diseases (e.g. unstable coronal heart disease);
• Any history of seizure disorder or hemorrhagic stroke;
• Past stereotactic neurosurgical intervention;
• Neurological disease (Abnormal PET-CT, MRI, EEG)
• Contraindications of MRI-examination, e.g. implanted cardiac pacemaker/ heart defibrillator;
• Contraindications of stereotactic intervention, e.g. increased bleeding disposition, cerebrovascular diseases (e.g. arteriovenous malfunction, aneurysms, systemic vascular diseases);
• HIV positive;
• Pregnancy and/or lactation;