Target Therapies Resistance Molecular Profiling in Patients With Neoplastic Disease

Non-interventional Study for the Determination of Molecular Resistance Profiling to Targeted Therapies in Patients With Neoplastic Disease

The main purpose of this study is to define the molecular profile of selected solid tumors. From each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. Whereas possible, vital tumor specimens will be inoculated and propagated in immunocompromised NOD/SCID mice to study the genetic correlations between genetic status and response to target drugs.

Inclusion Criteria:

Patients with at least one of the following selected solid tumors:

• Colorectal Cancer (primary or with synchronous/metachronous liver metastases)
• Prostate Cancer
• Head & Neck Tumors
• Gastric Cancer
• Glioblastoma
• Breast Cancer
• Hepatocarcinoma
• Biliary Tract Carcinoma
• Lung Cancer (primary)
• Rare Tumors (incidence ≤ 5x10-6)
• Metastatic Sarcoma
• Metastatic Melanoma

Exclusion Criteria:

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