Measurement of the Energy Metabolism of Peritoneal Dialysis Patients

Study in Calorimetric Room of the Energy Metabolism of Renal Impairment Patients Treated With Automated Peritoneal Dialysis

The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome.

The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.

The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome.

The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.

Inclusion Criteria:

• Patients Group DPA

  • Male patients
  • Aged 18 to 70 years
  • With end-stage renal disease
  • Treated by automatic peritoneal
  • Social security cover
  • Without acute events in the 3 months prior to inclusion
  • PCR < 30 mg/L
  • Written informed consent
  • Baecke activity score from 5 to 10

Healthy Volunteers

• Male patients
• Aged 18 to 70 years
• Patients matched by lean body mass (± 2 kgs) and age (± 5 years)
• Having a glomerular filtration rate estimated with the formula CKD-EPI creatinine > 60 mL / min / 1.73 m 2
• PCR < 3 mg/L
• Social security cover
• Written informed consent
• Baecke activity score from 5 to 10

Exclusion Criteria:

• • - Female

  • Type 1 or 2 diabetes requiring a antidiabetic treatment
  • Decompensated heart failure
  • Smoking more than 5 cigarettes a day
  • Alcoholic patients, drinking more than 3 glass of alcohol a day
  • Patient Corticotherapy in progress
  • Patient with evolutive acute pathology
  • Person who has participated in another study within the last 30 days or is in period of exclusion on the National File of Healthy Volunteers