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Previous studies have shown that vertigo is the symptoms that mostly affect quality of life in patients with vestibular schwannoma. There is still limited knowledge as to why some patients with this disorder develop vertigo, while others with the same diagnosis do not. The purpose of this study is to measure symptom-related quality of life and to relate this to objective disease characteristics at baseline.
This is a longitudinal observational study with data collected at baseline and after treatment.
Variables collected at baseline include age, sex, tumor size, location, type (cystic/solid), tumor side, symptom variables including Dizziness Handicap Inventory, Vertigo Symptom Scale Short Form, Haukeland Dizziness Questionnaire, Visual analog scale, Hospital Anxiety and Depression Scale, RAND-12, dynamic posturography, video-based head impulse test, bithermal caloric tests, ocular and cervical vestibular evoked myogenic potentials.
Follow-up data after 1 year are the same patient-reported outcomes as at baseline.
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| Measure | Description | Time Frame |
|---|---|---|
| Dizziness Handicap Inventory (DHI) | 25-item symptom score 0 - 100 points on dizziness handicap severity | Baseline and 1-year follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Vertigo Symptom Scale Short Form | 15-item symptom score 0 - 60 points on vertigo symptom quality | Baseline and 1-year follow-up |
| Haukeland Dizziness Questionnaire (HDQ-10) | 10-item symptom score 0 - 30 points on vertigo symptom severity |
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Inclusion Criteria:
Exclusion Criteria:
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All patients in Norway with newly diagnosed vestibular schwannoma (VS) are referred to Haukeland University Hospital for evaluation. The size of the study population therefore depends on the incidence of VS in Norway and the inclusion period. The incidence of VS in Norway is approximately 150 per year in a population of 5.2 million.
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| Name | Affiliation | Role |
|---|---|---|
| Frederik K Goplen, PhD | Haukeland University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Haukeland University Hospital | Bergen | Hordaland | 5009 | Norway |
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| ID | Term |
|---|---|
| D009464 | Neuroma, Acoustic |
| ID | Term |
|---|---|
| D009442 | Neurilemmoma |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
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| Baseline and 1-year follow-up |
| Vertigo Visual Analog Scale | 100 mm visual analog scale on vertigo symptom severity | Baseline and 1-year follow-up |
| Hospital Anxiety and Depression Scale (HADS) | 14-item anxiety and depression score 0 - 42 points | Baseline and 1-year follow-up |
| RAND-12 | 12-item health-related quality of life score | Baseline and 1-year follow-up |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009463 | Neuroma |
| D018317 | Nerve Sheath Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D003390 | Cranial Nerve Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D010524 | Peripheral Nervous System Neoplasms |
| D000160 | Vestibulocochlear Nerve Diseases |
| D012181 | Retrocochlear Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D010039 | Otorhinolaryngologic Neoplasms |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |