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The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SAH with DCI | Aneurysmal subarachnoid haemorrhage patients with delayed cerebral infarction | ||
| SAH nonDCI | Aneurysmal subarachnoid haemorrhage patients without delayed cerebral infarction | ||
| Control | Healthy volunteers |
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| Measure | Description | Time Frame |
|---|---|---|
| Circulating micro RNA concentrations | Serum micro RNA concentrations | Day 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Circulating micro RNA change | Changes of serum micro RNA concentrations between days 1,2,3,7 | Days 1,2,3,7 |
| Cerebrospinal fluid micro RNA concentrations | Cerebrospinal fluid micro RNA concentrations |
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Inclusion Criteria:
Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers
Exclusion Criteria:
Previous neurological diseases such as stroke or dementia
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| Name | Affiliation | Role |
|---|---|---|
| George KC Wong | Chinese University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Surgery, The Chinese University of Hong Kong | Hong Kong | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28442458 | Background | Lu G, Wong MS, Xiong MZQ, Leung CK, Su XW, Zhou JY, Poon WS, Zheng VZY, Chan WY, Wong GKC. Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. J Am Heart Assoc. 2017 Apr 25;6(4):e005363. doi: 10.1161/JAHA.116.005363. | |
| 26675167 | Background | Su XW, Chan AH, Lu G, Lin M, Sze J, Zhou JY, Poon WS, Liu Q, Zheng VZ, Wong GK. Circulating microRNA 132-3p and 324-3p Profiles in Patients after Acute Aneurysmal Subarachnoid Hemorrhage. PLoS One. 2015 Dec 16;10(12):e0144724. doi: 10.1371/journal.pone.0144724. eCollection 2015. |
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| ID | Term |
|---|---|
| D013345 | Subarachnoid Hemorrhage |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Serum
| Day 1,2,3,7 |
| Cerebrospinal fluid micro RNA change | Changes of cerebrospinal fluid micro RNA concentrations between days 1,2,3,7 | Days 1,2,3,7 |
| 22851612 | Background | Wong GK, Lam S, Ngai K, Wong A, Mok V, Poon WS; Cognitive Dysfunction after Aneurysmal Subarachnoid Haemorrhage Investigators. Evaluation of cognitive impairment by the Montreal cognitive assessment in patients with aneurysmal subarachnoid haemorrhage: prevalence, risk factors and correlations with 3 month outcomes. J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1112-7. doi: 10.1136/jnnp-2012-302217. Epub 2012 Jul 31. |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |