Study of the Reversibility of Vigilance Dysfunction at 6 Months of Continuous Positive Airways Pressure (CPAP) in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)

Study of the Reversibility of Vigilance Dysfunction at 6 Months of Continuous Positive Airways Pressure (CPAP) in Patients With Obstructive Sleep

It is a monocentric prospective pilot study in Poitiers University Hospital, specifically analyzing the vigilance disorders in the Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and their reversibility after 6 months of Continuous positive airways pressure (CPAP).

All subjects were administered a test of vigilance (Test of Attentional Performance) both before and after the 6 months of CPAP.

The main objective is the study of the reversibility of alertness disorders on the number of omissions in the subtest visual vigilance of the TAP ( (Test of Attentional Performance) at 6 months of CPAP in the OSAHS in patients with a memory complaint.

Inclusion Criteria:

• Patients aged 20-70 years

• Memory disorders without memory problems in episodic memory

• Presence of polysomnography of a obstructive sleep apnea/hypopnea syndrome (OSAHS) requiring Continuous positive airways pressure

  • Moderate OSAHS (Apnea Hypopnea Index ≥ 15 / hour with arousals ≥ 10)
  • Severe OSAHS (Apnea Hypopnea Index ≥ 30 / h)

Exclusion Criteria:

• Age <20 years or ≥ 70 years
• Neurodegenerative disease (Alzheimer's disease, Parkinson's disease)
• Dysthyroidism
• Severe depression, schizophrenia, bipolar disorder
• Treatment with an effect on cognition: hypnotics, sedative
• Chronic Obstructive Pulmonary Disease
• Chronic alcoholism, other addictions
• Contraindications to Magnetic Resonance Imaging
• Refusal of equipment