Biomarker Establishment for Superior Treatment of PTSD

Biomarker Establishment for Superior Treatment of PTSD

The purpose of Biomarker Establishment for Superior Treatment of PTSD is to accelerate research on the discovery of biological, neurological and neuroimaging markers for Post- Traumatic Stress Disorder (PTSD). The investigators hope to validate and extend the network efficiency and verbal memory biomarker for PTSD. The investigators hope to learn whether there are pretreatment biological factors that can predict response to therapy. They want to do this by understanding the brain network function, relating EEG to functional magnetic resonance imaging, and application of network analysis tool.

Inclusion Criteria:

• Diagnosis of PTSD by VA clinicians and acceptance into PE or CPT treatment as part of the PCT
• Veterans of any era

Exclusion Criteria:

• MRI safety contraindications
• Active, uncontrolled medical illness
• Acute suicidality
• Current substance dependence
• Current use of thyroid medication or active hyper/hypothyroidism
• Neurological disorder affecting the CNS Seg stroke, epilepsy, tumorW or penetrating head injury
• Use of PRN within 48 hours of the MRI/EEG