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| Name | Class |
|---|---|
| Rutgers University | OTHER |
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The purpose of this study is to test resting state functional Magnetic Resonance Imaging (rsfMRI) scans to see if rsfMRI scans are better than the standard task based fMRI scans at diagnosing or monitoring central nervous system lymphoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Central Nervous System Lymphoma | Participants will have non-Hodgkins lymphoma involving the brain (primary or secondary) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resting State fMRI (rsfMRI) | Diagnostic Test | rsfMRI before receiving High-dose chemotherapy with autologous stem cell transplantation/HDC-ASCT (pre-HDC-ASCT), at approximately 3 months (+/- 2 weeks) after HDC-ASCT (early post-HDC-ASCT) and approximately 6months (+/- 2 weeks) after HDC-ASCT (late post-HDC-ASCT). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in resting state brain networks over time in participants with central nervous system lymphoma before and after treatment with high-dose chemotherapy with autologous stem cell transplantation through resting state fMRI results | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Potential research subjects will be identified by a member of the patient's treatment team, listed protocol investigators, or Neuroradiology research team at Memorial Sloan Kettering Cancer Center (MSKCC).
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| Name | Affiliation | Role |
|---|---|---|
| Behroze Vachha, MD, PhD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States |
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| Label | URL |
|---|---|
| Related Info | View source |
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| Auditory Attention and Executive Functions Test | Other |
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| Memory Test | Other | The Hopkins Verbal Learning Test-Revised (HVLT-R): The HVLT-R is a test of verbal learning and memory. |
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| Motor Speed Test | Other | Grooved Pegboard Test (GPT)-Dominant Hand and Non-Dominant Hand. It is a timed test of manual dexterity, in which the time to completion is scored separately for each hand. |
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| Self Reported Quality of Life Questionnaire | Other | The Functional Assessment of Cancer Therapy-Brain Cancer (FACT-BR Version 4) consists of 46 questions with five domains assessing physical well-being, social/family well-being, emotional well-being, functional well being, additional concerns. The neuropsychological and QOL assessments will be performed by a neuropsychologist or by a trained RSA under the neuropsychologist's direct supervision. |
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